Anti-MAdCAM1 抗体 [MECA-367] (Biotin) (ab25021)

製品の概要

  • 製品名Anti-MAdCAM1 antibody [MECA-367] (Biotin)
    MAdCAM1 一次抗体 製品一覧
  • 製品の詳細
    Rat monoclonal [MECA-367] to MAdCAM1 (Biotin)
  • 標識Biotin
  • アプリケーション適用あり: Other, Flow Cyt, IHC-Fr, Blocking, IP, WBmore details
  • 種交差性
    交差種: Mouse
  • 免疫原

    Endothelial cells isolated from BALB/c mouse mesenteric and peripheral lymph nodes.

  • エピトープab25021 reacts with an epitope located in the first domain of MAdCAM1.
  • 特記事項


    ab25021 blocks MAdCAM-1-dependent binding in vitro and lymphocyte homing to Peyer’s patch HEV In vivo.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab25021 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
Other Use at an assay dependent concentration.
AP Use at an assay dependent concentration.
Flow Cyt Use at an assay dependent concentration. ab18445-Rat monoclonal IgG2a, is suitable for use as an isotype control with this antibody.
IHC-Fr Use a concentration of 1 µg/ml.
Blocking Use at an assay dependent concentration.
IP Use at an assay dependent concentration.
WB Use at an assay dependent concentration. Predicted molecular weight: 42 kDa.

ターゲット情報

  • 機能Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding.
  • 組織特異性Highly expressed on high endothelial venules (HEV) and lamina propia venules found in the small intestine, and to a lesser extent in the colon and spleen. Very low levels of expression found in pancreas and brain. Not expressed in the thymus, prostate, ovaries, testis, heart, placenta, lung, liver, skeletal muscle, kidney or peripheral blood leukocytes.
  • 配列類似性Contains 2 Ig-like (immunoglobulin-like) domains.
  • 翻訳後修飾The Ser/Thr-rich mucin-like domain may provide possible sites for O-glycosylation.
  • 細胞内局在Membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Addressin mucosal antibody
    • hMAdCAM 1 antibody
    • hMAdCAM-1 antibody
    • MACAM1 antibody
    • MADCA_HUMAN antibody
    • MAdCAM 1 antibody
    • MAdCAM-1 antibody
    • Madcam1 antibody
    • Mucosal addressin cell adhesion molecule 1 antibody
    • Mucosal vascular addressin cell adhesion molecule 1 antibody
    see all

Anti-MAdCAM1 antibody [MECA-367] (Biotin) (ab25021) 使用論文

ab25021 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"