製品の概要

  • 製品名Anti-MAdCAM1 antibody [314G8] (Phycoerythrin)
    MAdCAM1 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [314G8] to MAdCAM1 (Phycoerythrin)
  • 標識Phycoerythrin. Ex: 488nm, Em: 575nm
  • 特異性ab58430 recognises human mucosal addressin cell adhesion molecule 1 (MAdCAM1). MAdCAM1 is expressed on high endothelial venules of Peyer's patches and mesenteric lymph nodes. MAdCAM1 expression has also been reported in the gut lamina propria but clone 314G8 does not recognise MAdCAM1 in these tissues. Clone 314G8 reacts with the ligand-binding first Ig domain and reports suggest that a splice variant exists in the gut which is not recognised by clone 314G8. Clone 314G8 is reported to block the interaction of MAdCAM1 with alpha 4 beta 7 (in press).
  • アプリケーション適用あり: Flow Cytmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant soluble MAdCAM1 fc fusion protein.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab58430 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
Flow Cyt
  • 追加情報Flow Cyt: Use neat - 1/10. Use 10ul of the suggested working dilution to label 106 cells in 100ul.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding.
    • 組織特異性Highly expressed on high endothelial venules (HEV) and lamina propia venules found in the small intestine, and to a lesser extent in the colon and spleen. Very low levels of expression found in pancreas and brain. Not expressed in the thymus, prostate, ovaries, testis, heart, placenta, lung, liver, skeletal muscle, kidney or peripheral blood leukocytes.
    • 配列類似性Contains 2 Ig-like (immunoglobulin-like) domains.
    • 翻訳後修飾The Ser/Thr-rich mucin-like domain may provide possible sites for O-glycosylation.
    • 細胞内局在Membrane.
    • Information by UniProt
    • 参照データベース
    • 別名
      • Addressin mucosal antibody
      • hMAdCAM 1 antibody
      • hMAdCAM-1 antibody
      • MACAM1 antibody
      • MADCA_HUMAN antibody
      • MAdCAM 1 antibody
      • MAdCAM-1 antibody
      • Madcam1 antibody
      • Mucosal addressin cell adhesion molecule 1 antibody
      • Mucosal vascular addressin cell adhesion molecule 1 antibody
      see all

    Anti-MAdCAM1 antibody [314G8] (Phycoerythrin) (ab58430) 使用論文

    This product has been referenced in:
    • Dianzani C  et al. B7h triggering inhibits umbilical vascular endothelial cell adhesiveness to tumor cell lines and polymorphonuclear cells. J Immunol 185:3970-9 (2010). Flow Cyt ; Human . Read more (PubMed: 20817864) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"