製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to MACROD1
  • アプリケーション
    適用あり: ICC/IF, IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    antigen sequence: SFLKGLSDKQ REEHYFCKDF VRLKKIPTWK EMAKGVAVKV EEPRYKKDKQ LNEKISLLRS DITKLEV, corresponding to amino acids of Human MACROD1.

  • ポジティブ・コントロール
    • Human colon tissue.

アプリケーション

Our Abpromise guarantee covers the use of ab122688 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ICC/IF Use a concentration of 1 - 4 µg/ml.

Recommend PFA Fixation and Triton X-100 treatment

IHC-P 1/200 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

ターゲット情報

  • 機能
    Plays a role in estrogen signaling. Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen. May play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward mechanism that activates ESR1 transactivation. Could be an ESR1 coactivator, providing a positive feedback regulatory loop for ESR1 signal transduction. Could be involved in invasive growth by down-regulating CDH1 in endometrial cancer cells. Enhances ESR1-mediated transcription activity.
  • 関連疾患
    Note=A chromosomal aberration involving MACROD1 is found in acute leukemia. Translocation t(11;21)(q13;q22) that forms a RUNX1-MACROD1 fusion protein.
  • 配列類似性
    Contains 1 Macro domain.
  • Information by UniProt
  • 参照データベース
  • 別名
    • LRP16 antibody
    • MACD1_HUMAN antibody
    • MACRO domain containing 1 antibody
    • MACRO domain-containing protein 1 antibody
    • Macrod1 antibody
    • O-acetyl-ADP-ribose deacetylase MACROD1 antibody
    • Protein LRP16 antibody
    see all

画像

  • Immunofluorescent staining of Human cell line A-431 shows positivity in mitochondria. Recommended concentration of ab122688 1-4 µg/ml. Cells treated with PFA/Triton X-100.
  • ab122688, at 1/200 dilution, staining MACROD1 in paraffin-embedded Human colon tissue by Immunohistochemistry.

参考文献

This product has been referenced in:
  • Ahmed S  et al. Loss of the Mono-ADP-ribosyltransferase, Tiparp, Increases Sensitivity to Dioxin-induced Steatohepatitis and Lethality. J Biol Chem 290:16824-40 (2015). Read more (PubMed: 25975270) »

See 1 Publication for this product

レビューと Q&A

There are currently no Customer reviews or Questions for ab122688.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

登録