製品の概要
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製品名Anti-MACF1 antibody
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製品の詳細Rabbit polyclonal to MACF1
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由来種Rabbit
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アプリケーション適用あり: WB, ELISAmore details
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種交差性交差種: Mouse, Rat
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免疫原
Synthetic peptide corresponding to Mouse MACF1 aa 3651-3846.
Sequence:KLSPQELT ALREKLHQAK EQYEVLQERT RVAQKELEEA VTSALQQETE KSKAATELAE NKRKIDALLD WVASVGSSER KPQASLPGME QFSGACLEKQ TLAATDGHVD VNQVPETLDR QYELMKARHQ ELLSQQQNFI VATQSVQSFL DQHSHNLTPE ERQKLQEKLG ELKEQYAASL ARSEAELKQT QALRDEL
Database link: Q9QXZ0 -
ポジティブ･コントロール
- Mouse kidney tissue.
製品の特性
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製品の状態Liquid
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保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
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バッファーConstituents: Proprietary component, Whole serum
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Concentration information loading... -
精製度Immunogen affinity purified
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ポリ/モノポリクローナル
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アイソタイプIgG
関連製品
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Compatible Secondaries
アプリケーション
Our Abpromise guarantee covers the use of ab117418 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB | 1/500. Predicted molecular weight: 832 kDa. | |
| ELISA | 1/10000. |
ターゲット情報
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関連性Microtubule-actin crosslinking factor 1 (MACF1/ACF7) belongs to spectraplakin family of proteins which also includes mammalian Bpag1/dystonin, Drosophila Short Stop (Shot) and Caenorhabditis elegans Vab-10. These are large actin-microtubule linker molecules that are essential for various biological processes such as neuronal degeneration, wound healing, gastrulation. MACF1, located on mouse chromosome 4D2.2, was found to play an important role during neurogenesis- it was shown that MACF1 regulates the organization of neuronal microtubules which is essential for axon extension. Furthermore, MACF1 is required in controlling focal adhesion assembly and dynamics. MACF1 behaves as an actin-regulated ATPase and it has the ability to target microtubules that track along F-actin to focal adhesions. MACF1 was also implicated in regulating filopodia formation.
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細胞内局在Cytoplasmic, microtubule. Plasma membrane. Golgi apparatus.
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参照データベース
- Entrez Gene: 11426 Mouse
- Entrez Gene: 362587 Rat
- SwissProt: Q9QXZ0 Mouse
- SwissProt: D3ZHV2 Rat
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別名
- ABP620 antibody
- Acf7 antibody
- Aclp7 antibody
see all
画像
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Immunocytochemistry/ Immunofluorescence - Anti-MACF1 antibody (ab117418)ab117418 at 1/500 dilution staining MACF1 in Mouse kidney tissue by Immunofluorescence.
プロトコール
参考文献
ab117418 has not yet been referenced specifically in any publications.
レビューと Q&A
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"