Anti-Lysosomal acid lipase/LAL 抗体 (ab89771)
Key features and details
- Mouse polyclonal to Lysosomal acid lipase/LAL
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-Lysosomal acid lipase/LAL antibody
Lysosomal acid lipase/LAL 一次抗体 製品一覧 -
製品の詳細
Mouse polyclonal to Lysosomal acid lipase/LAL -
由来種
Mouse -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Human -
免疫原
Recombinant full length protein within Human Lysosomal acid lipase/LAL. The exact immunogen sequence used to generate this antibody is proprietary information. If additional detail on the immunogen is needed to determine the suitability of the antibody for your needs, please contact our Scientific Support team to discuss your requirements. (AAH12287.1)
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ポジティブ・コントロール
- Human pancreas tissue lysate, Lysosomal acid lipase/LAL transfected 293T cell lysate.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
バッファー
pH: 7.40
Constituent: 100% PBS -
Concentration information loading...
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精製度
Protein A purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab89771の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB |
Use a concentration of 1 µg/ml. Predicted molecular weight: 45 kDa.
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特記事項 |
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WB
Use a concentration of 1 µg/ml. Predicted molecular weight: 45 kDa. |
ターゲット情報
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機能
Crucial for the intracellular hydrolysis of cholesteryl esters and triglycerides that have been internalized via receptor-mediated endocytosis of lipoprotein particles. Important in mediating the effect of LDL (low density lipoprotein) uptake on suppression of hydroxymethylglutaryl-CoA reductase and activation of endogenous cellular cholesteryl ester formation. -
関連疾患
Defects in LIPA are the cause of Wolman disease (WOD) [MIM:278000]. WOD is a severe manifestation of LIPA deficiency, leading to the accumulation of cholesteryl esters and triglycerides in most tissues of the body. WOD occurs in infancy and is nearly always fatal before the age of 1 year.
Defects in LIPA are the cause of cholesteryl ester storage disease (CESD) [MIM:278000]. CESD is a mild manifestation of LIPA deficiency, leading to the accumulation of cholesteryl esters and triglycerides in most tissues of the body. It is characterized by late-onset. -
配列類似性
Belongs to the AB hydrolase superfamily. Lipase family. -
細胞内局在
Lysosome. - Information by UniProt
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参照データベース
- Entrez Gene: 3988 Human
- Omim: 278000 Human
- SwissProt: P38571 Human
- Unigene: 643030 Human
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別名
- Acid cholesteryl ester hydrolase antibody
- CESD antibody
- cholesterol ester hydrolase antibody
see all
画像
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Anti-Lysosomal acid lipase/LAL antibody (ab89771) at 1 µg/ml + human pancreas tissue lysate at 50 µg
Predicted band size: 45 kDa
Observed band size: 45 kDa -
All lanes : Anti-Lysosomal acid lipase/LAL antibody (ab89771) at 1 µg/ml
Lane 1 : Lysosomal acid lipase/LAL transfected 293T cell lysate
Lane 2 : Non-transfected lysate
Lysates/proteins at 25 µg per lane.
Predicted band size: 45 kDa
Observed band size: 45 kDa
データシートおよび資料
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Datasheet download
参考文献 (0)
ab89771 は論文での使用が確認できていません。