製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to LYK5
  • 特異性
    The amino acid sequence used as immunogen is 100% homologous in isoforms 1, 2, 3 and 4 of Human LYK5.
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Cow, Dog
  • 免疫原

    Synthetic peptide consisting of a portion of amino acids 300-350 of Human LYK5 (isoform 1).

  • ポジティブ・コントロール
    • A549 cell lysate.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab47103 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 0.5 - 2 µg/ml. Detects a band of approximately 32 kDa (predicted molecular weight: 48 kDa).

ターゲット情報

  • 関連性
    Members of the STE-20 like kinase family are known to stimulate MAPK pathways by directly activating MAPKKK. LYK5 is a novel pseudokinase member of this family consisting of a STE-20 like kinase domain but lacks several residues that are required for its catalytic activity. It specifically binds LKB1 and plays a key role in regulating the tumor suppressor activities of LKB1. It functions as an upstream activator of LKB1 and also directs the sub-cellular localization of LKB1 by anchoring it in the cytoplasm. LYK5-LKB1 interaction results in phosphorylation of LYK5 and enhanced autophosphorylation of LKB1.
  • 細胞内局在
    Cytoplasmic and Nuclear
  • 参照データベース
  • 別名
    • Protein kinase LYK5 antibody
    • Serologically defined breast cancer antigen NY BR 96 antibody
    • STE20 related adapter protein antibody
    • STRAD alpha antibody
    • STRAD antibody
    see all

画像

  • All lanes : Anti-LYK5 antibody (ab47103) at 1 µg/ml

    Lane 1 : A549 cell lysate
    Lane 2 : A549 cell lysate with immunizing peptide


    Predicted band size : 48 kDa
    Observed band size : 34 kDa (why is the actual band size different from the predicted?)
    Additional bands at : 22 kDa. We are unsure as to the identity of these extra bands.

プロトコール

参考文献

ab47103 has not yet been referenced specifically in any publications.

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