LY 379268, Group II mGlu agonist (ab120196)
Key features and details
- Group II mGlu agonist. Systemically active.
- CAS Number: 191471-52-0
- Purity: > 99%
- Soluble in water to 25 mM (with heating)
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
LY 379268, Group II mGlu agonist -
製品の詳細
Group II mGlu agonist. Systemically active. -
生理活性の詳細
Highly potent and systemically active mGlu2 and mGlu3 agonist. EC50 values are 2.69 and 4.48 nM for hmGlu2 and hmGlu3, respectively and displays >80-fold selectivity over group I and group III receptors. Effective in several animal models of stroke, epilepsy, drug abuse, schizophrenia, and pain.
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精製度
> 99% -
CAS 番号
191471-52-0 -
構造式
製品の特性
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体系名
(1R,4R,5S,6R)-4-amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid -
分子量
187.15 -
分子式
C7H9NO5 -
PubChem 登録番号
10197984 -
保存方法
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in water to 25 mM (with heating) -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
OC(=O)[C@]2(N)CO[C@H]1[C@H](C(=O)O)[C@H]12 -
由来
Synthetic
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研究分野
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (8)
ab120196 は 8 報の論文で使用されています。
- Špirková A et al. Glutamate can act as a signaling molecule in mouse preimplantation embryos†. Biol Reprod 107:916-927 (2022). PubMed: 35746896
- Liu J et al. Abnormal Glu/mGluR2/3/PI3K pathway in the hippocampal neurovascular unit leads to diabetes-related depression. Neural Regen Res 16:727-733 (2021). PubMed: 33063735
- Bragina L et al. Differential expression of metabotropic glutamate and GABA receptors at neocortical glutamatergic and GABAergic axon terminals. Front Cell Neurosci 9:345 (2015). PubMed: 26388733
- Yin S et al. Selective actions of novel allosteric modulators reveal functional heteromers of metabotropic glutamate receptors in the CNS. J Neurosci 34:79-94 (2014). PubMed: 24381270
- Cuccurazzu B et al. Upregulation of mGlu2 Receptors via NF-?B p65 Acetylation Is Involved in the Proneurogenic and Antidepressant Effects of Acetyl-L-Carnitine. Neuropsychopharmacology 38:2220-30 (2013). PubMed: 23670591
- Klakotskaia D et al. Effects of group II and III metabotropic glutamate receptor ligands on conditioned taste aversion learning. Behav Brain Res 253:9-16 (2013). PubMed: 23827202
- Gosnell HB et al. mGluR8 modulates excitatory transmission in the bed nucleus of the stria terminalis in a stress-dependent manner. Neuropsychopharmacology 36:1599-607 (2011). PubMed: 21451497
- Rylander D et al. Pharmacological modulation of glutamate transmission in a rat model of L-DOPA-induced dyskinesia: effects on motor behavior and striatal nuclear signaling. J Pharmacol Exp Ther 330:227-35 (2009). PubMed: 19357321