製品の概要

  • 製品名LY 354740
  • 製品の詳細
    Group II mGlu agonist. Systemically active.
  • 生理活性の詳細Highly potent and selective agonist at mGlu2 and mGlu3 receptors (EC50 values are 5.1 and 24.3 nM, respectively). Displays no agonist or antagonist activity at mGlu1a, mGlu5a, mGlu4 or mGlu7 receptors at concentrations up to 100 μM. Orally and systemically active. Anxiolytic and antiaddictive effects in vivo.
  • 精製度> 98%

製品の特性

    LY 354740 (ab120173) 使用論文

    This product has been referenced in:
    • Linden AM  et al. Anxiolytic-like activity of the mGLU2/3 receptor agonist LY354740 in the elevated plus maze test is disrupted in metabotropic glutamate receptor 2 and 3 knock-out mice. Psychopharmacology (Berl) 179:284-91 (2005). Read more (PubMed: 15619115) »
    • Klodzinska A  et al. Potential anti-anxiety, anti-addictive effects of LY 354740, a selective group II glutamate metabotropic receptors agonist in animal models. Neuropharmacology 38:1831-9 (1999). Read more (PubMed: 10608278) »
    • Schoepp DD  et al. LY354740 is a potent and highly selective group II metabotropic glutamate receptor agonist in cells expressing human glutamate receptors. Neuropharmacology 36:1-11 (1997). Read more (PubMed: 9144636) »

    See 1 Publication for this product

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