製品の概要

  • 製品名
    LY 344864 hydrochloride
  • 製品の詳細
    Selective, potent 5-HT1F agonist
  • 生理活性の詳細
    Selective, potent, full 5-HT1F agonist (EC50 = 3 nM). Selectivity is 80-fold greater than for other 5-HT receptor subtypes, Ki values are 0.53 (5-HT1A), 0.549 (5-HT1B), 0.575 (5-HT1D), 1.415 (5-HT1E), 3.935 (5-HT2A), 1.695 (5-HT2B), 3.499 (5-HT2C) and 4.851 (5-HT7). Able to reduce central sensitization and dural inflammation in vivo.
  • 精製度
    > 98%
  • 特記事項
    Sold under license from Eli Lilly and company

製品の特性

参考文献

This product has been referenced in:
  • Amrutkar DV  et al. mRNA expression of 5-hydroxytryptamine 1B, 1D, and 1F receptors and their role in controlling the release of calcitonin gene-related peptide in the rat trigeminovascular system. Pain 153:830-8 (2012). Read more (PubMed: 22305629) »
  • Mitsikostas DD  et al. 5-Hydroxytryptamine(1B/1D) and 5-hydroxytryptamine1F receptors inhibit capsaicin-induced c-fos immunoreactivity within mouse trigeminal nucleus caudalis. Cephalalgia 22:384-94 (2002). Read more (PubMed: 12110114) »
  • Phebus LA  et al. Characterization of LY344864 as a pharmacological tool to study 5-HT1F receptors: binding affinities, brain penetration and activity in the neurogenic dural inflammation model of migraine. Life Sci 61:2117-26 (1997). Read more (PubMed: 9395253) »

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