LY-333531 hydrochloride, protein kinase Cbeta inhibitor (ab219866)
Key features and details
- Potent, isozyme-selective protein kinase Cβ (PKCβ) inhibitor
- CAS Number: 169939-93-9
- Purity: > 98%
- Soluble in DMSO to 20 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
LY-333531 hydrochloride, protein kinase Cbeta inhibitor -
製品の詳細
Potent, isozyme-selective protein kinase Cβ (PKCβ) inhibitor -
別名
- LY333531 hydrochloride
- Ruboxistaurin
- Ruboxistaurin hydrochloride
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生理活性の詳細
Potent, isozyme-selective inhibitor of protein kinase Cβ (PKCβ). Competitively inhibits PKCßI and PKCßII (IC50 values are 4.7 and 5.9 nM respectively). 76- and 61-fold selective for inhibition of PKCßI and PKCßII in comparison to PKCα, respectively. Exhibits selectivity for PKC over other ATP-dependent kinases, including protein kinase A, casein kinase and src).
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精製度
> 98% -
特記事項
This product is manufactured by BioVision, an Abcam company and was previously called 2156 LY-333,531 hydrochloride. 2156-250 is the same size as the 250 µg size of ab219866.
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CAS 番号
169939-93-9 -
構造式
製品の特性
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体系名
(9S)-9-[(Dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-dimethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20(19H)-dione hydrochloride -
分子量
505.01 -
分子式
C28H28N4O3.HCl -
PubChem 登録番号
9870785 -
保存方法
Shipped at 4°C. Store at -20°C. Store under desiccating conditions. -
溶解性
Soluble in DMSO to 20 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
CN(C)C[C@@H]1CCN2C=C(C3=CC=CC=C32)C4=C(C5=CN(CCO1)C6=CC=CC=C65)C(=O)NC4=O.Cl -
由来
Synthetic
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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Datasheet download
参考文献 (1)
ab219866 は 1 報の論文で使用されています。
- Zhang H et al. Signaling pathways involved in NMDA-induced suppression of M-channels in corticotropin-releasing hormone neurons in central amygdala. J Neurochem 161:478-491 (2022). PubMed: 35583089