製品の概要

  • 製品名
    LY 272015 hydrochloride
  • 製品の詳細
    Highly potent, selective 5-HT2B antagonist
  • 生理活性の詳細
    Highly potent, selective 5-HT2B receptor antagonist (Ki values are 0.75, 21.63 and 28.7 nM for 5-HT2B, 5-HT2C and 5-HT2A receptors, respectively). Displays antihypertensive activity in vivo.
  • 精製度
    > 99%

製品の特性

参考文献

This product has been referenced in:
  • Russell A  et al. 5-Hydroxytryptamine(2B) receptor function is enhanced in the N(omega)-nitro-L-arginine hypertensive rat. J Pharmacol Exp Ther 303:179-87 (2002). Read more (PubMed: 12235249) »
  • Watts SW & Fink GD 5-HT2B-receptor antagonist LY-272015 is antihypertensive in DOCA-salt-hypertensive rats. Am J Physiol 276:H944-52 (1999). Read more (PubMed: 10070078) »
  • Audia JE  et al. Potent, selective tetrahydro-beta-carboline antagonists of the serotonin 2B (5HT2B) contractile receptor in the rat stomach fundus. J Med Chem 39:2773-80 (1996). Read more (PubMed: 8709108) »

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