製品の概要

  • 製品名Anti-Lunatic Fringe antibody
    Lunatic Fringe 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Lunatic Fringe
  • アプリケーション適用あり: WB, ELISAmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Horse, Guinea pig, Cow, Saccharomyces cerevisiae
  • 免疫原

    Synthetic peptide corresponding to a region of human Lunatic Fringe

  • ポジティブ・コントロール
    • Fetal muscle lysate.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab80439 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 42 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
ELISA Use at an assay dependent concentration.

ELISA titre using peptide based assay: 1/62500.

ターゲット情報

  • 機能Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Decreases the binding of JAGGED1 to NOTCH2 but not that of DELTA1. Essential mediator of somite segmentation and patterning.
  • 関連疾患Defects in LFNG are the cause of spondylocostal dysostosis type 3 (SCDO3) [MIM:609813]. An autosomal recessive condition of variable severity associated with vertebral and rib segmentation defects. The main skeletal malformations include fusion of vertebrae, hemivertebrae, fusion of certain ribs, and other rib malformations. Deformity of the chest and spine (severe scoliosis, kyphoscoliosis and lordosis) is a natural consequence of the malformation and leads to a dwarf-like appearance. As the thorax is small, infants frequently have respiratory insufficiency and repeated respiratory infections resulting in life-threatening complications in the first year of life.
  • 配列類似性Belongs to the glycosyltransferase 31 family.
  • 翻訳後修飾A soluble form may be derived from the membrane form by proteolytic processing.
  • 細胞内局在Golgi apparatus membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • 3-N-acetylglucosaminyltransferase lunatic fringe antibody
    • Beta-1 antibody
    • Beta-13-N-acetylglucosaminyltransferase lunatic fringe antibody
    • lfng antibody
    • LFNG_HUMAN antibody
    • O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase antibody
    • SCDO3 antibody
    see all

Anti-Lunatic Fringe antibody 画像

  • Anti-Lunatic Fringe antibody (ab80439) at 1 µg/ml + fetal muscle lysate at 10 µg

    Secondary
    HRP conjugated anti Rabbit IgG at 1/50000 dilution

    Predicted band size : 42 kDa
    Observed band size : 36 kDa (why is the actual band size different from the predicted?)

Anti-Lunatic Fringe antibody (ab80439) 使用論文

ab80439 has not yet been referenced specifically in any publications.

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