製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to LTK
  • アプリケーション
    適用あり: ELISA, WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to amino acids 57-73 of Human LTK.

  • ポジティブ・コントロール
    • Placenta lysate.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab5507 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA 1/1000.
WB 1/100 - 1/500. Detects a band of approximately 92 kDa (predicted molecular weight: 96 kDa).

ターゲット情報

  • 機能
    Orphan receptor with a tyrosine-protein kinase activity. The exact function of this protein is not known. Studies with chimeric proteins (replacing its extracellular region with that of several known growth factor receptors, such as EGFR and CSFIR) demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival. Signaling appears to involve the PI3 kinase pathway. Involved in regulation of the secretory pathway involving endoplasmic reticulum (ER) export sites (ERESs) and ER to Golgi transport.
  • 組織特異性
    Expressed in non-hematopoietic cell lines and T- and B-cell lines.
  • 関連疾患
    Note=Genetic variations in LTK that cause up-regulation of the PI3K pathway may possibly contribute to susceptibility to abnormal proliferation of self-reactive B cells and, therefore, to systemic lupus erythematosus (SLE). SLE is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue, thought to represent a failure of the regulatory mechanisms of the autoimmune system.
  • 配列類似性
    Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
    Contains 1 protein kinase domain.
  • 細胞内局在
    Membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Leukocyte receptor tyrosine kinase antibody
    • Leukocyte tyrosine kinase antibody
    • Leukocyte tyrosine kinase receptor antibody
    • Ltk antibody
    • LTK_HUMAN antibody
    • Protein tyrosine kinase 1 antibody
    • TYK 1 antibody
    • TYK1 antibody
    see all

画像



  • Predicted band size : 96 kDa

プロトコール

参考文献

ab5507 has not yet been referenced specifically in any publications.

レビューと Q&A

There are currently no Customer reviews or Questions for ab5507.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

登録