製品の概要

  • 製品名Anti-LTK antibody
    LTK 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to LTK
  • 特異性This antibody is expected to react with isoforms one and two of human LTK.
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat
  • 免疫原

    Synthetic peptide : A sequence taken from within amino acids 800-864 of human LTK.

  • ポジティブ・コントロール
    • Human K562 cell lysate

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab47072 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 0.5 - 2 µg/ml. Detects a band of approximately 95 kDa (predicted molecular weight: 91 kDa).

ターゲット情報

  • 機能Orphan receptor with a tyrosine-protein kinase activity. The exact function of this protein is not known. Studies with chimeric proteins (replacing its extracellular region with that of several known growth factor receptors, such as EGFR and CSFIR) demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival. Signaling appears to involve the PI3 kinase pathway. Involved in regulation of the secretory pathway involving endoplasmic reticulum (ER) export sites (ERESs) and ER to Golgi transport.
  • 組織特異性Expressed in non-hematopoietic cell lines and T- and B-cell lines.
  • 関連疾患Note=Genetic variations in LTK that cause up-regulation of the PI3K pathway may possibly contribute to susceptibility to abnormal proliferation of self-reactive B cells and, therefore, to systemic lupus erythematosus (SLE). SLE is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue, thought to represent a failure of the regulatory mechanisms of the autoimmune system.
  • 配列類似性Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
    Contains 1 protein kinase domain.
  • 細胞内局在Membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Leukocyte receptor tyrosine kinase antibody
    • Leukocyte tyrosine kinase antibody
    • Leukocyte tyrosine kinase receptor antibody
    • Ltk antibody
    • LTK_HUMAN antibody
    • Protein tyrosine kinase 1 antibody
    • TYK 1 antibody
    • TYK1 antibody
    see all

Anti-LTK antibody 画像

  • Anti-LTK antibody (ab47072) at 1 µg/ml + human K562 cell lysate

    Predicted band size : 91 kDa
    Observed band size : 95 kDa (why is the actual band size different from the predicted?)
    Additional bands at : 120 kDa,33 kDa,40 kDa,50 kDa,63 kDa. We are unsure as to the identity of these extra bands.

Anti-LTK antibody (ab47072) 使用論文

ab47072 has not yet been referenced specifically in any publications.

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There are currently no Abreviews or Questions for ab47072.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"