製品の概要

  • 製品名Anti-LTK antibody
    LTK 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to LTK
  • アプリケーション適用あり: WB, IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide corresponding to a region within amino acids 800-864 of Human LTK, conjugated to KLH.

  • ポジティブ・コントロール
    • Human colon, lamina propria plasma cells

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab115273 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 2 - 5 µg/ml. Predicted molecular weight: 92 kDa.
IHC-P Use a concentration of 10 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

ターゲット情報

  • 機能Orphan receptor with a tyrosine-protein kinase activity. The exact function of this protein is not known. Studies with chimeric proteins (replacing its extracellular region with that of several known growth factor receptors, such as EGFR and CSFIR) demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival. Signaling appears to involve the PI3 kinase pathway. Involved in regulation of the secretory pathway involving endoplasmic reticulum (ER) export sites (ERESs) and ER to Golgi transport.
  • 組織特異性Expressed in non-hematopoietic cell lines and T- and B-cell lines.
  • 関連疾患Note=Genetic variations in LTK that cause up-regulation of the PI3K pathway may possibly contribute to susceptibility to abnormal proliferation of self-reactive B cells and, therefore, to systemic lupus erythematosus (SLE). SLE is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue, thought to represent a failure of the regulatory mechanisms of the autoimmune system.
  • 配列類似性Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
    Contains 1 protein kinase domain.
  • 細胞内局在Membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Leukocyte receptor tyrosine kinase antibody
    • Leukocyte tyrosine kinase antibody
    • Leukocyte tyrosine kinase receptor antibody
    • Ltk antibody
    • LTK_HUMAN antibody
    • Protein tyrosine kinase 1 antibody
    • TYK 1 antibody
    • TYK1 antibody
    see all

Anti-LTK antibody 画像

  • Human colon lamina propria plasma cells (formalin fixed, paraffin embedded) stained with ab115273 at 10 µg/ml, followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-LTK antibody (ab115273) 使用論文

ab115273 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab115273.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"