製品の概要

  • 製品名Anti-LTBP2 antibody
    LTBP2 一次抗体 製品一覧
  • 製品の詳細
    Goat polyclonal to LTBP2
  • アプリケーション適用あり: WBmore details
  • 種交差性

    交差が予測される動物種: Mouse, Human
  • 免疫原

    Synthetic peptide:

    C-NSTSSTEDLPDHD

    with a Cysteine residue linker, corresponding to internal sequence amino acids 1568-1580 of Human LTBP2 (NP_000419.1).

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • バッファーpH: 7.30
    Preservative: 0.02% Sodium azide
    Constituents: 99% Tris buffered saline, 0.5% BSA
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • 特記事項(精製)Purified from Goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab121005 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 195 kDa. Preliminary experiments in Mouse and Rat Eye lysates gave no specific signal but low background (at antibody concentration up to 1µg/ml).

ターゲット情報

  • 機能May play an integral structural role in elastic-fiber architectural organization and/or assembly.
  • 組織特異性Expressed in lung, weakly expressed in heart, placenta, liver and skeletal muscle.
  • 関連疾患Defects in LTBP2 are the cause of primary congenital glaucoma type 3D (GLC3D) [MIM:613086]. An autosomal recessive form of primary congenital glaucoma (PCG). PCG is characterized by marked increase of intraocular pressure at birth or early childhood, large ocular globes (buphthalmos) and corneal edema. It results from developmental defects of the trabecular meshwork and anterior chamber angle of the eye that prevent adequate drainage of aqueous humor.
    Defects in LTBP2 are the cause of microspherophakia (MCSPH) [MIM:251750]. It is a rare disease characterized by smaller and more spherical lenses than normal bilaterally, an increased anteroposterior thickness of the lens and highly myopic eyes. Lens dislocation or subluxation may occur, leading to defective accommodation.
  • 配列類似性Belongs to the LTBP family.
    Contains 20 EGF-like domains.
    Contains 4 TB (TGF-beta binding) domains.
  • ドメインAssociates covalently with small latent TGF-beta complex via Repeat B and Repeat C.
  • 翻訳後修飾Contains hydroxylated asparagine residues.
  • 細胞内局在Secreted. Localized in nuchal ligament and aorta to the fibrillin-containing, microfibrillar component of elastic fibers.
  • Information by UniProt
  • 参照データベース
  • 別名
    • C14orf141 antibody
    • Chromosome 14 open reading frame 141 antibody
    • Latent TGF beta binding protein 2 antibody
    • Latent transforming growth factor beta binding protein 2 antibody
    • Latent-transforming growth factor beta-binding protein 2 antibody
    • LTBP 2 antibody
    • LTBP 3 antibody
    • LTBP-2 antibody
    • Ltbp2 antibody
    • LTBP2_HUMAN antibody
    • LTBP3 antibody
    • MSTP 031 antibody
    • MSTP031 antibody
    see all

Anti-LTBP2 antibody (ab121005) 使用論文

ab121005 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"