製品の概要

  • 製品名Anti-LRSAM1 antibody
    LRSAM1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to LRSAM1
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Full length protein, corresponding to amino acids 1-723 of Human LRSAM1 (NP_001005373.1).

  • ポジティブ・コントロール
    • Human liver tissue lysate, HeLa cell lysate.

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab103677 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 84 kDa.

ターゲット情報

  • 機能E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (HIV-1 viral proteins) cargos.
  • 組織特異性Highly expressed in adult spinal cord motoneurons as well as in fetal spinal cord and muscle tissue.
  • パスウェイProtein modification; protein ubiquitination.
  • 関連疾患Charcot-Marie-Tooth disease 2P (CMT2P) [MIM:614436]: An axonal form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Neuropathies of the CMT2 group are characterized by signs of axonal degeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy. Nerve conduction velocities are normal or slightly reduced. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • 配列類似性Contains 6 LRR (leucine-rich) repeats.
    Contains 1 RING-type zinc finger.
    Contains 1 SAM (sterile alpha motif) domain.
  • ドメインThe coiled coil domains interact with the SB domain of TSG101.
    The PTAP motifs mediate the binding to UEV domains.
  • 細胞内局在Cytoplasm. Displays a punctuate distribution and localizes to a submembranal ring.
  • Information by UniProt
  • 参照データベース
  • 別名
    • CMT2P antibody
    • E3 ubiquitin protein ligase LRSAM1 antibody
    • E3 ubiquitin-protein ligase LRSAM1 antibody
    • EC 6.3.2.- antibody
    • FLJ31641 antibody
    • hTAL antibody
    • Leucine rich repeat and sterile alpha motif containing 1 antibody
    • Leucine rich repeat and sterile alpha motif containing protein 1 antibody
    • Leucine-rich repeat and sterile alpha motif-containing protein 1 antibody
    • LRSAM1 antibody
    • LRSM1_HUMAN antibody
    • OTTHUMP00000022174 antibody
    • OTTHUMP00000022175 antibody
    • RIFLE antibody
    • TAL antibody
    • Tsg101 associated ligase antibody
    • Tsg101-associated ligase antibody
    see all

Anti-LRSAM1 antibody 画像

  • Anti-LRSAM1 antibody (ab103677) at 5 µg/ml + Human liver tissue lysate at 50 µg

    Predicted band size : 84 kDa
  • Anti-LRSAM1 antibody (ab103677) at 5 µg/ml + HeLa cell lysate at 50 µg

    Predicted band size : 84 kDa
  • All lanes : Anti-LRSAM1 antibody (ab103677) at 5 µg/ml

    Lane 1 : LSRAM1 transfected 293T cell lysate
    Lane 2 : 293T non-transfected cell lysate

    Lysates/proteins at 50 µg per lane.


    Predicted band size : 84 kDa

Anti-LRSAM1 antibody (ab103677) 使用論文

ab103677 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"