製品の概要

  • 製品名Anti-LRDD antibody
    LRDD 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to LRDD
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat
  • 免疫原

    Synthetic peptide corresponding to a region within N-terminal amino acids 143-192 (

    RLQGNPLGEASPDAPSSPVAALIPEMPRLFLTSDLDSFPVTPQGCSVTLA

    ) of Human LRDD isoform 3.

  • ポジティブ・コントロール
    • Human Fetal Liver Lysate

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • バッファーPreservative: None
    Constituents: 2% Sucrose, PBS
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab99149 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 83 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

ターゲット情報

  • 関連性The death domain (DD) containing protein PIDD is a p53 target gene in an erythroleukemia cell line that undergoes G1 phase arrest and subsequent apoptosis after p53 expression. Independently, PIDD was also described as a DD-containing protein with unknown function. The N-terminal region of PIDD contains seven leucine-rich repeats (LRRs), a protein interaction motif found in various proteins with diverse functions, followed by two ZU-5 domains and a C-terminal DD. PIDD forms a complex with caspase-2 and the adaptor protein RAIDD. Increased PIDD expression results in spontaneous activation of caspase-2 and sensitization to apoptosis by genotoxic stimuli, via interaction with caspase-2 and CRADD/RAIDD. PIDD also promotes apoptosis downstream of p53 as component of the DNA damage/stress response pathway that connects p53/TP53 to apoptosis. PIDD has also been shown to interact with NEMO/IKBKG and RIP1 and enhance sumoylation and ubiquitination of NEMO/IKBKG, an important component for activation of the transcription factor NF-kappa-B.
  • 細胞内局在Cytoplasm. Nucleus.
  • 参照データベース
  • 別名
    • DKFZp434D229 antibody
    • Leucine rich repeats and death domain containing antibody
    • Leucine-rich repeats and death domain containing antibody
    • MGC16925 antibody
    • p53-induced protein with a death domain antibody
    • PIDD antibody
    see all

Anti-LRDD antibody 画像

  • Anti-LRDD antibody (ab99149) at 1 µg/ml + Human Fetal Liver Lysate at 10 µg

    Predicted band size : 83 kDa

Anti-LRDD antibody (ab99149) 使用論文

ab99149 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab99149.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"