製品の概要

  • 製品名Anti-LPP antibody
    LPP 一次抗体 製品一覧
  • 製品の詳細
    Goat polyclonal to LPP
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Cow, Dog, Chimpanzee, Rhesus monkey, Orangutan
  • 免疫原

    Synthetic peptide:

    C-RNDSDPTYGQQGHP

    , corresponding to internal sequence amino acids 310-323 of Human LPP (NP_005569.1).

  • ポジティブ・コントロール
    • HepG2 cell lysate and Human placenta lysate.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • バッファーpH: 7.30
    Preservative: 0.02% Sodium azide
    Constituents: 0.5% BSA, Tris buffered saline
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • 特記事項(精製)ab99281 was purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab99281 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 0.1 - 0.3 µg/ml. Detects a band of approximately 85 kDa (predicted molecular weight: 66 kDa). An approximately 85kDa band is observed in Human Placenta lysates and in lysates of the cell line HepG2. The observed molecular weight corresponds to earlier findings with different antibodies from other commercial sources.

ターゲット情報

  • 機能May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus.
  • 組織特異性Expressed in a wide variety of tissues but no or very low expression in brain and peripheral leukocytes.
  • 関連疾患Note=A chromosomal aberration involving LPP is associated with a subclass of benign mesenchymal tumors known as lipomas. Translocation t(3;12)(q27-q28;q13-q15) with HMGA2 is shown in lipomas.
    Note=A chromosomal aberration involving LPP is associated with pulmonary chondroid hamartomas. Translocation t(3;12)(q27-q28;q14-q15) with HMGA2 is detected in pulmonary chondroid hamartomas.
    Note=A chromosomal aberration involving LPP is associated with parosteal lipomas. Translocation t(3;12)(q28;q14) with HMGA2 is also shown in one parosteal lipoma.
    Note=A chromosomal aberration involving LPP is associated with acute monoblastic leukemia. Translocation t(3;11)(q28;q23) with MLL is associated with acute monoblastic leukemia.
  • 配列類似性Belongs to the zyxin/ajuba family.
    Contains 3 LIM zinc-binding domains.
  • 細胞内局在Nucleus. Cytoplasm. Cell junction. Cell membrane. Found in the nucleus, in the cytoplasm and at cell adhesion sites. Shuttles between the cytoplasm and the nucleus. It has been found in sites of cell adhesion such as cell-to-cell contact and focal adhesion which are membrane attachment sites of cells to the extracellular matrix. Mainly nuclear when fused with HMGA2/HMGIC and MLL.
  • Information by UniProt
  • 参照データベース
  • 別名
    • DKFZp779O0231 antibody
    • FLJ30652 antibody
    • FLJ41512 antibody
    • LIM domain containing preferred translocation partner in lipoma antibody
    • LIM domain-containing preferred translocation partner in lipoma antibody
    • LIM protein antibody
    • Lipoma preferred partner antibody
    • Lipoma-preferred partner antibody
    • lpp antibody
    • LPP_HUMAN antibody
    see all

Anti-LPP antibody 画像

  • Anti-LPP antibody (ab99281) at 0.1 µg/ml + HepG2 cell lysate in RIPA buffer at 35 µg
    Developed using the ECL technique

    Predicted band size : 66 kDa

Anti-LPP antibody (ab99281) 使用論文

ab99281 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"