製品の概要

  • 製品名
    LP-44
  • 製品の詳細
    Highly potent, selective 5-HT7 agonist
  • 生理活性の詳細
    Highly potent, selective 5-HT7 agonist (Ki = 0.22 nM). Shows >200 and >1000-fold selectivity over 5-HT1A and 5-HT2A receptors, respectively. Supresses REM sleep.
  • 精製度
    > 99%

製品の特性

参考文献

This product has been referenced in:
  • Leopoldo M  et al. Serotonin 5-HT7 receptor agents: Structure-activity relationships and potential therapeutic applications in central nervous system disorders. Pharmacol Ther 129:120-48 (2011). Read more (PubMed: 20923682) »
  • Monti JM  et al. The serotonin 5-HT7 receptor agonist LP-44 microinjected into the dorsal raphe nucleus suppresses REM sleep in the rat. Behav Brain Res 191:184-9 (2008). Read more (PubMed: 18466985) »
  • Leopoldo M  et al. Structure-affinity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinealkylamides, a new class of 5-hydroxytryptamine7 receptor agents. J Med Chem 47:6616-24 (2004). Read more (PubMed: 15588097) »

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