製品の概要

  • 製品名LNK peptide

製品の詳細

  • 由来Synthetic
  • アミノ酸配列
    • 配列NGPALQPSSPC

関連製品

特性

Our Abpromise guarantee covers the use of ab45607 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking - Blocking peptide for Anti-LNK antibody (ab21203)

  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

関連情報

  • 別名
    • IDDM20
    • Lymphocyte adapter protein
    • Lymphocyte specific adapter protein
    • Lymphocyte specific adapter protein Lnk
    • Lymphocyte-specific adapter protein Lnk
    • SH2B adapter protein 3
    • SH2B adaptor protein 3
    • Sh2b3
    • SH2B3_HUMAN
    • Signal transduction protein Lnk
    see all
  • 機能Links T-cell receptor activation signal to phospholipase C-gamma-1, GRB2 and phosphatidylinositol 3-kinase.
  • 組織特異性Preferentially expressed by lymphoid cell lines.
  • 関連疾患Genetic variations in SH2B3 are associated with susceptibility to celiac disease type 13 (CELIAC13)[MIM:612011]; also known as susceptibility to gluten-sensitive enteropathy type 13. Celiac disease is a multifactorial disorder of the small intestine that is influenced by both environmental and genetic factors. It is characterized by malabsorption resulting from inflammatory injury to the mucosa of the small intestine after the ingestion of wheat gluten or related rye and barley proteins. In its classic form, celiac disease is characterized in children by malabsorption and failure to thrive.
    Genetic variations in SH2B3 are associated with susceptibility to insulin-dependent diabetes mellitus (IDDM) [MIM:222100]; also known as diabetes mellitus type 1. IDDM normally starts in childhood or adolescence and is caused by the body's own immune system which destroys the insulin-producing beta cells in the pancreas. Classical features are polydipsia, polyphagia and polyuria, due to hyperglycemia-induced osmotic diuresis.
  • 配列類似性Belongs to the SH2B adapter family.
    Contains 1 PH domain.
    Contains 1 SH2 domain.
  • 翻訳後修飾Tyrosine phosphorylated by LCK.
  • Information by UniProt

LNK peptide (ab45607) 使用論文

ab45607 has not yet been referenced specifically in any publications.

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