製品の概要

  • 製品名Anti-LMBRD1 antibody
    LMBRD1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to LMBRD1
  • 特異性LMBRD1 antibody is predicted to not cross-react with other LMBRD1 family members.
  • アプリケーション適用あり: ICC/IF, WB, IHC-Pmore details
  • 種交差性
    交差種: Mouse, Rat, Human
  • 免疫原

    An 18 amino acid peptide from the C-terminus of Human LMBRD1 (NP_060838)

  • ポジティブ・コントロール
    • Human Brain Tissue Lysate

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab105419 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ICC/IF Use a concentration of 20 µg/ml.
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 61 kDa.
IHC-P Use at an assay dependent concentration.

ターゲット情報

  • 機能Probable lysosomal cobalamin transporter. Required to export cobalamin from lysosomes allowing its conversion to cofactors. Isoform 3 may play a role in the assembly of hepatitis delta virus (HDV).
  • 組織特異性Isoform 3 is expressed in liver.
  • 関連疾患Defects in LMBRD1 are the cause of methylmalonic aciduria and homocystinuria type cblF (MMAFHC) [MIM:277380]; also known as homocystinuria-megaloblastic anemia complementation type F. MMAFHC is a disorder of cobalamin metabolism characterized by decreased levels of the coenzymes adenosylcobalamin (AdoCbl) and methylcobalamin (MeCbl). It is due to accumulation of free cobalamin in lysosomes, thus hindering its conversion to cofactors. Clinical features include developmental delay, stomatitis, glossitis, seizures and methylmalonic aciduria responsive to vitamin B12.
  • 配列類似性Belongs to the LIMR family. LMBRD1 subfamily.
  • 翻訳後修飾N-glycosylated.
  • 細胞内局在Lysosome membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • HDAg-L-interacting protein NESI antibody
    • LMBD1_HUMAN antibody
    • LMBR1 domain-containing protein 1 antibody
    • lmbrd1 antibody
    • Nuclear export signal-interacting protein antibody
    • Probable lysosomal cobalamin transporter antibody
    see all

Anti-LMBRD1 antibody 画像

  • Immunofluorescence of LMBRD1 in Human brain tissue with ab105419 at 20 ug/mL.
  • Immunohistochemistry of LMBRD1 in Human brain tissue with ab105419 at 2.5 μg/mL.

  • Anti-LMBRD1 antibody (ab105419) at 1 µg/ml + Human brain tissue lysate at 15 µg

    Predicted band size : 61 kDa

Anti-LMBRD1 antibody (ab105419) 使用論文

ab105419 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"