製品の概要

  • 製品名Anti-LMBR1 antibody
    LMBR1 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal to LMBR1
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant fragment: SRMFTVMGQL LVKPTILEDL DEQIYIITLE EEALQRRLNG LSSSVEYNIM ELEQELENVK TLKTKLERRK KASAWERNLV YP, corresponding to amino acids 214-296 of Human LMBR1

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • バッファーPreservative: None
    PBS, pH 7.2
  • Concentration information loading...
  • 精製度Protein G purified
  • ポリ/モノモノクローナル
  • アイソタイプIgG2a
  • 軽鎖の種類kappa
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab56402 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
  • 追加情報WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Putative membrane receptor.
    • 組織特異性Widely expressed with strongest expression in heart and pancreas.
    • 関連疾患Defects in LMBR1 are associated with preaxial polydactyly type 2 (PPD2) [MIM:174500]; also known as polydactyly of triphalangeal thumb. Polydactyly consists of duplication of the distal phalanx. The thumb in PPD2 is usually opposable and possesses a normal metacarpal. The mutations do not change the normal expression of LMBR1, but alter the expression of SHH by disrupting a long-range, cis-regulatory element of that gene.
      Defects in LMBR1 are the cause of acheiropody (ACHP) [MIM:200500]. Acheiropody is a very rare condition characterized by bilateral congenital amputations of the hands and feet. The specific malformative phenotype consists of a complete amputation of the distal epiphysis of the humerus, amputation of the tibial diaphysis, and aplasia of the radius, ulna, fibula, and of all the bones of the hands and feet. This syndrome of autosomal recessive inheritance has only been observed in Brazil so far.
      Defects in LMBR1 are a cause of syndactyly type 4 (SDYT4) [MIM:186200]. SDYT4 is a very rare congenital distal limb malformation characterized by complete bilateral syndactyly (involving all digits 1 to 5). A frequent association with polydactyly (with six metacarpals and six digits) has been reported. Feet are affected occasionally. The condition is inherited as an autosomal dominant trait.
    • 配列類似性Belongs to the LIMR family.
    • 細胞内局在Membrane.
    • Information by UniProt
    • 参照データベース
    • 別名
      • ACHP antibody
      • C7orf2 antibody
      • DIF 14 antibody
      • DIF14 antibody
      • Differentiation related gene 14 antibody
      • Differentiation related gene 14 protein antibody
      • Differentiation-related gene 14 protein antibody
      • FLJ11665 antibody
      • Limb region 1 homolog (mouse) antibody
      • Limb region 1 homolog antibody
      • Limb region 1 protein antibody
      • Limb region 1 protein homolog antibody
      • LMBR 1 antibody
      • LMBR1 antibody
      • LMBR1_HUMAN antibody
      • OTTHUMP00000211720 antibody
      • PPD 2 antibody
      • PPD2 antibody
      • TPT antibody
      see all

    Anti-LMBR1 antibody 画像

    • Western blot against tagged recombinant protein immunogen using ab56402 LMBR1 antibody at 1ug/ml. Predicted band size of immunogen is 35 kDa

    Anti-LMBR1 antibody (ab56402) 使用論文

    ab56402 has not yet been referenced specifically in any publications.

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    There are currently no Abreviews or Questions for ab56402.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"