製品の概要

  • 製品名
    Anti-LLGL1 antibody [4D11] (FITC)
    LLGL1 一次抗体 製品一覧
  • 製品の詳細
    Rat monoclonal [4D11] to LLGL1 (FITC)
  • 標識
    FITC. Ex: 493nm, Em: 528nm
  • アプリケーション
    適用あり: Flow Cytmore details
  • 種交差性
    交差種: Mouse
  • 免疫原

    Large granular lymphocytes (LGL) enriched from C57BL/6N mouse liver

  • ポジティブ・コントロール
    • Mouse splenocytes.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab95802 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
Flow Cyt Use 0.125-0.25µg for 105-8 cells. Perform staining in a final volume of 100 µl.



ab18446-Rat monoclonal IgG2a, is suitable for use as an isotype control with this antibody.

ターゲット情報

  • 機能
    Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells.
  • 組織特異性
    Expressed in brain, kidney, and muscle but is barely seen in heart and placenta. Down-regulated or lost in all cell lines and in most of the tumor samples analyzed. Loss was associated with advanced stage of the disease.
  • 配列類似性
    Belongs to the WD repeat L(2)GL family.
    Contains 14 WD repeats.
  • 翻訳後修飾
    Phosphorylated upon DNA damage, probably by ATM or ATR (By similarity). Phosphorylated at least at Ser-663 by PRKCI.
  • 細胞内局在
    Cytoplasm > cytoskeleton. Localized to the lateral membrane during the polarization and formation cell-cell contacts.
  • Information by UniProt
  • 参照データベース
  • 別名
    • DLG4 antibody
    • DLG4, formerly antibody
    • Hugl 1 antibody
    • HUGL antibody
    • Hugl-1 antibody
    • HUGL1 antibody
    • Human homolog to the D-lgl gene protein antibody
    • L2GL1_HUMAN antibody
    • Lethal giant larvae homolog 1 (Drosophila) antibody
    • Lethal giant larvae homolog 1 antibody
    • Lethal(2) giant larvae protein homolog 1 antibody
    • LLGL antibody
    • Llgl1 antibody
    • Ly 49G2 antibody
    • Ly49G2 antibody
    • Mgl1 antibody
    • Mlgl antibody
    see all

画像

  • Staining of C57BL/6 splenocytes with Anti-Mouse CD49b (Integrin alpha2) PE and 0.125 µg of Rat IgG2a k Isotype Control FITC (left) or 0.125 µg of ab95802 (right). Total viable cells were used for analysis.

プロトコール

参考文献

This product has been referenced in:
  • Ortaldo JR  et al. The Ly-49 family: regulation of cytotoxicity and cytokine production in murine CD3+ cells. J Immunol 160:1158-65 (1998). Read more (PubMed: 9570529) »
  • Mason LH  et al. Cloning and functional characteristics of murine large granular lymphocyte-1: a member of the Ly-49 gene family (Ly-49G2) J Exp Med 182:293-303 (1995). Read more (PubMed: 7629495) »

See all 3 Publications for this product

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