製品の概要

  • 製品名Anti-LKB1 antibody
    LKB1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to LKB1
  • 特異性Detects endogenous levels of total LKB1 protein.
  • アプリケーション適用あり: WB, ELISAmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse
  • 免疫原

    Synthesized non phosphopeptide derived from human LKB1 around the phosphorylation site of serine 334 (W-R-SP-M-T)

  • ポジティブ・コントロール
    • Extracts from HT-29 cells

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab79355 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/1000. Predicted molecular weight: 48 kDa.
ELISA 1/20000.

ターゲット情報

  • 機能Essential role in G1 cell cycle arrest. Phosphorylates and activates members of the AMPK-related subfamily of protein kinases. Tumor suppressor.
  • 組織特異性Ubiquitously expressed. Strongest expression in testis and fetal liver.
  • 関連疾患Defects in STK11 are a cause of Peutz-Jeghers syndrome (PJS) [MIM:175200]. PJS is a rare hereditary disease in which there is predisposition to benign and malignant tumors of many organ systems. PJS is an autosomal dominant disorder characterized by melanocytic macules of the lips, multiple gastrointestinal hamartomatous polyps and an increased risk for various neoplasms, including gastrointestinal cancer.
    Defects in STK11 have been associated with testicular tumors (TEST) [MIM:273300]. A common solid malignancy in males. Germ cell tumors of the testis constitute 95% of all testicular neoplasms.
  • 配列類似性Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. LKB1 subfamily.
    Contains 1 protein kinase domain.
  • 翻訳後修飾Phosphorylated by a cAMP-dependent protein kinase.
  • 細胞内局在Nucleus. Cytoplasm. Relocates to the cytoplasm when bound to CAB39 and STRAD or CAB39 and ALS2CR2.
  • Information by UniProt
  • 参照データベース
  • 別名
    • hLKB1 antibody
    • Liver kinase B1 antibody
    • LKB1 antibody
    • PJS antibody
    • Polarization related protein LKB1 antibody
    • Renal carcinoma antigen NY-REN-19 antibody
    • Serine/Threonine Kinase 11 antibody
    • Serine/threonine protein kinase 11 antibody
    • Serine/threonine protein kinase LKB1 antibody
    • Serine/threonine protein kinase STK11 antibody
    • Serine/threonine-protein kinase 11 antibody
    • Serine/threonine-protein kinase LKB1 antibody
    • Serine/threonine-protein kinase XEEK1 antibody
    • Stk11 antibody
    • STK11_HUMAN antibody
    see all

Anti-LKB1 antibody 画像

  • All lanes : Anti-LKB1 antibody (ab79355) at 1/500 dilution

    Lane 1 : extracts from HT-29 cells at 10 µg
    Lane 2 : extracts from HT-29 cells at 10 µg/ml with immunizing peptide at 10 µg


    Predicted band size : 48 kDa
    Observed band size : 55 kDa (why is the actual band size different from the predicted?)

Anti-LKB1 antibody (ab79355) 使用論文

ab79355 has not yet been referenced specifically in any publications.

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