機能Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1. In vitro, inhibits caspase-3 and proteolytic activation of pro-caspase-9. Isoform 1 blocks staurosporine-induced apoptosis. Isoform 2 blocks etoposide-induced apoptosis.
組織特異性Isoform 1 and isoform 2 are expressed at very low levels or not detectable in most adult tissues. Detected in adult heart, placenta, lung, lymph node, spleen and ovary, and in several carcinoma cell lines. Isoform 2 is detected in fetal kidney, heart and spleen, and at lower levels in adult brain, skeletal muscle and peripheral blood leukocytes.
配列類似性Belongs to the IAP family. Contains 1 BIR repeat. Contains 1 RING-type zinc finger.
細胞内局在Nucleus. Cytoplasm. Nuclear, and in a filamentous pattern throughout the cytoplasm.
ab97350, at a 1/100 dilution, staining Livin in paraffin embedded Cal27 xenograft by Immunohistochemistry.
Anti-Livin antibody (ab97350) 使用論文
This product has been referenced in:
Saladi SV et al. BRG1 promotes survival of UV-irradiated melanoma cells by cooperating with MITF to activate the melanoma inhibitor of apoptosis gene. Pigment Cell Melanoma Res26:377-91 (2013).
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