Anti-Lipoprotein lipase 抗体 (ab123134)

製品の概要

  • 製品名
    Anti-Lipoprotein lipase antibody
    Lipoprotein lipase 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Lipoprotein lipase
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region within internal sequence amino acids 299-327 of Human Lipoprotein lipase (NP_000228.1)

  • ポジティブ・コントロール
    • HL-60 cell line lysates

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab123134 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/100 - 1/500. Predicted molecular weight: 53 kDa.

ターゲット情報

  • 機能
    The primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (VLDL). Binding to heparin sulfate proteogylcans at the cell surface is vital to the function. The apolipoprotein, APOC2, acts as a coactivator of LPL activity in the presence of lipids on the luminal surface of vascular endothelium.
  • 関連疾患
    Defects in LPL are the cause of lipoprotein lipase deficiency (LPL deficiency) [MIM:238600]; also known as familial chylomicronemia or hyperlipoproteinemia type I. LPL deficiency chylomicronemia is a recessive disorder usually manifesting in childhood. On a normal diet, patients often present with abdominal pain, hepatosplenomegaly, lipemia retinalis, eruptive xanthomata, and massive hypertriglyceridemia, sometimes complicated with acute pancreatitis.
  • 配列類似性
    Belongs to the AB hydrolase superfamily. Lipase family.
    Contains 1 PLAT domain.
  • 翻訳後修飾
    Tyrosine nitration after lipopolysaccharide (LPS) challenge down-regulates the lipase activity.
  • 細胞内局在
    Cell membrane. Secreted. Locates to the plasma membrane of microvilli of hepatocytes with triacyl-glycerol-rich lipoproteins (TRL). Some of the bound LPL is then internalized and located inside non-coated endocytic vesicles.
  • Information by UniProt
  • 参照データベース
  • 別名
    • EC 3.1.1 antibody
    • EC 3.1.1.34 antibody
    • HDLCQ11 antibody
    • LIPD antibody
    • LIPL_HUMAN antibody
    • Lipoprotein lipase antibody
    • LPL antibody
    • LPL protein antibody
    • MGC137861 antibody
    see all

画像

  • Anti-Lipoprotein lipase antibody (ab123134) at 1/100 dilution + HL-60 cell line lysates at 35 µg/ml

    Predicted band size : 53 kDa

プロトコール

参考文献

ab123134 has not yet been referenced specifically in any publications.

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