Anti-Lipoprotein a 抗体 (ab104453)

製品の概要

  • 製品名Anti-Lipoprotein a antibody
    Lipoprotein a 一次抗体 製品一覧
  • 製品の詳細
    Goat polyclonal to Lipoprotein a
  • アプリケーション適用あり: ELISA, IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Purified Human Lipoprotein a

  • ポジティブ・コントロール
    • Human liver tissue

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab104453 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA Use at an assay dependent dilution.
IHC-P Use a concentration of 20 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

ターゲット情報

  • 関連性Lipoprotein(a) (Lp(a)) is a lipoprotein subclass assembled in the blood from low density lipoprotein (LDL) molecules and apolipoprotein-a (apo-a). Lp(a) recruits inflammatory cells through interaction with Mac-1 integrin. High Lp(a) in blood is a risk factor for coronary heart disease, cerebrovascular disease, atherosclerosis, thrombosis, and stroke. Lp(a) concentrations may be affected by disease states, but are only moderately affected by diet, exercise and other environmental factors. Lipid-reducing drugs have no effect on Lp(a) concentration. High Lp(a) predicts risk of early atherosclerosis similar to high LDL, but in advanced atherosclerosis, Lp(a) is a risk factor independent of LDL, indicating a coagulant risk of plaque thrombosis. Apo(a) contains domains that are very similar to plasminogen (PLG). Lp(a) accumulates in the vessel wall and inhibits binding of PLG to the cell surface, reducing plasmin generation which increases clotting. This inhibition also promotes proliferation of smooth muscle cells. These unique features of Lp(a) suggest a role in the generation of clots and atherosclerosis.
  • 参照データベース
  • 別名
    • AK38 antibody
    • Antiangiogenic AK38 protein antibody
    • apo(a) antibody
    • APOA antibody
    • apolipoprotein(a) antibody
    • LP antibody
    • lp(a) antibody
    • LPA antibody
    see all

Anti-Lipoprotein a antibody 画像

  • ab104453, at 20 µg/ml, staining Lipoprotein a in formalin-fixed, paraffin-embedded Human Liver by Immunohistochemistry, followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-Lipoprotein a antibody (ab104453) 使用論文

ab104453 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"