製品の概要

  • 製品名Anti-LIPH antibody
    LIPH 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to LIPH
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Rabbit, Horse, Guinea pig, Cow, Cat, Dog
  • 免疫原

    Synthetic peptide corresponding to internal sequence amino acids 259-308 (LRESCTITAY PCDSYQDYRN GKCVSCGTSQ KESCPLLGYY ADNWKDHLRG) of Human LIPH (NP_640341).

  • ポジティブ・コントロール
    • THP1 cell lysate.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab118303 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 51 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

ターゲット情報

  • 機能Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG).
  • 組織特異性Present in intestine (at protein level). Expressed in colon, prostate, kidney, pancreas, ovary, testis, intestine, lung and pancreas. Expressed at lower level in brain, spleen and heart. In hair, it is prominently expressed in hair follicles, including the stem cell-rich bulge region.
  • 関連疾患Defects in LIPH are the cause of hypotrichosis localized autosomal recessive type 2 (LAH2) [MIM:604379]; also known as alopecia universalis congenita Mari type. A condition characterized by the presence of less than the normal amount of hair. Affected individuals have sparse or absent scalp, axillary and body hair and sparse eyebrows and eyelashes.
    Defects in LIPH are the cause of woolly hair autosomal recessive type 2 (ARWH2) [MIM:604379]. A hair shaft disorder characterized by fine and tightly curled hair. Compared to normal curly hair that is observed in some populations, woolly hair grows slowly and stops growing after a few inches. Under light microscopy, woolly hair shows some structural anomalies, including trichorrexis nodosa and tapered ends. Some individuals may present with hypotrichosis.
  • 配列類似性Belongs to the AB hydrolase superfamily. Lipase family.
  • 細胞内局在Secreted. Membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • AH antibody
    • ARWH2 antibody
    • LAH2 antibody
    • Lipase H antibody
    • Lipase member H antibody
    • LIPH antibody
    • LIPH_HUMAN antibody
    • LPD lipase related protein antibody
    • LPD lipase-related protein antibody
    • LPDLR antibody
    • Membrane associated phosphatidic acid selective phospholipase A1 alpha antibody
    • Membrane bound phosphatidic acid selective phospholipase A1 antibody
    • Membrane-associated phosphatidic acid-selective phospholipase A1-alpha antibody
    • mPA PLA1 antibody
    • mPA-PLA1 alpha antibody
    • MPAPLA1 antibody
    • OTTHUMP00000210343 antibody
    • OTTHUMP00000210344 antibody
    • Phospholipase A1 member B antibody
    • PLA1B antibody
    see all

Anti-LIPH antibody 画像

  • Anti-LIPH antibody (ab118303) at 1 µg/ml + THP1 cell lysate at 10 µg

    Predicted band size : 51 kDa

Anti-LIPH antibody (ab118303) 使用論文

ab118303 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"