製品の概要

  • 製品名Anti-LIN7B antibody
    LIN7B 一次抗体 製品一覧
  • 製品の詳細
    Goat polyclonal to LIN7B
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Mouse, Rat
    交差が予測される動物種: Cow, Dog, Human, Pig
  • 免疫原

    Synthetic peptide:

    AALVEPLGLERDVS

    , corresponding to N terminal amino acids 2-15 of Human LIN7B.

  • ポジティブ・コントロール
    • Mouse or Rat brain
  • 特記事項GenBank Accession Number – NP_071448.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • バッファーPreservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris-saline. pH 7.3
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • 特記事項(精製)Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab5967 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 0.5 - 2 µg/ml. Detects a band of approximately 25 kDa (predicted molecular weight: 23 kDa).

ターゲット情報

  • 機能Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. May increase the amplitude of ACCN3 acid-evoked currents by stabilizing the channel at the cell surface.
  • 配列類似性Belongs to the lin-7 family.
    Contains 1 L27 domain.
    Contains 1 PDZ (DHR) domain.
  • ドメインThe kinase interacting site is required for proper delivery of ERBB2 to the basolateral membrane.
    The PDZ domain regulates endocytosis and recycling of the receptor at the membrane.
    The L27 domain mediates interaction with CASK and is involved in the formation of multimeric complexes and the association of LIN7 to membranes.
  • 細胞内局在Cell membrane. Basolateral cell membrane. Cell junction. Cell junction > synapse > postsynaptic cell membrane > postsynaptic density. Cell junction > tight junction. Cell junction > synapse > synaptosome. Enriched in synaptosomes and at epithelial cell-cell junctions (By similarity). Mainly basolateral in renal epithelial cells.
  • Information by UniProt
  • 参照データベース
  • 別名
    • hVeli2 antibody
    • hLin7B antibody
    • hVeli2 antibody
    • Lin 7 homolog B C elegans antibody
    • LIN 7B antibody
    • Lin 7b protein likely ortholog of mouse LIN 7B mammalian LIN 7 protein 2 antibody
    • Lin-7B antibody
    • LIN7B antibody
    • LIN7B_HUMAN antibody
    • MALS 2 antibody
    • MALS-2 antibody
    • MALS2 antibody
    • Mammalian lin seven protein 2 antibody
    • Mammalian lin-seven protein 2 antibody
    • Protein lin 7 homolog B antibody
    • Protein lin-7 homolog B antibody
    • VELI 2 antibody
    • Veli-2 antibody
    • VELI2 antibody
    • Vertebrate lin 7 homolog 2 antibody
    • Vertebrate lin-7 homolog 2 antibody
    see all

Anti-LIN7B antibody 画像

Anti-LIN7B antibody (ab5967) 使用論文

ab5967 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab5967.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"