Anti-Leptin Receptor 抗体 (ab7212)

製品の概要

  • 製品名
    Anti-Leptin Receptor antibody
    Leptin Receptor 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Leptin Receptor
  • 特異性
    Recombinant and natural mouse OB receptor.
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Mouse
  • 免疫原

    Recombinant fragment, corresponding to amino acids 217-376 of Mouse Leptin Receptor. Expressed in E. coli

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab7212 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
  • 追加情報
    WB: 1/2000. Predicted molecular weight: 120-140 kDa. The native leptin receptor is a homodimer held together with disulfide bonds. On a reducing SDS-PAGE, bands may appear as approximately 60 kDa subunits. Further variations in size is possible and is due to glycosylation.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能
      Receptor for obesity factor (leptin). On ligand binding, mediates signaling through JAK2/STAT3. Involved in the regulation of fat metabolism and, in a hematopoietic pathway, required for normal lymphopoiesis. May play a role in reproduction. Can also mediate the ERK/FOS signaling pathway.
    • 組織特異性
      Isoform A is expressed in fetal liver and in hematopoietic tissues and choroid plexus. In adults highest expression in heart, liver, small intestine, prostate and ovary. Low level in lung and kidney. Isoform B is highly expressed in hypothalamus.
    • 配列類似性
      Belongs to the type I cytokine receptor family. Type 2 subfamily.
      Contains 4 fibronectin type-III domains.
      Contains 1 Ig-like (immunoglobulin-like) domain.
    • ドメイン
      The cytoplasmic domain may be essential for intracellular signal transduction by activation of JAK tyrosine kinase and STATs.
      The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
      The box 1 motif is required for JAK interaction and/or activation.
    • 翻訳後修飾
      On ligand binding, phosphorylated on two conserved C-terminal tyrosine residues (isoform B only) by JAK2. Tyr-986 is required for complete binding and activation of PTPN11, ERK/FOS activation and, for interaction with SOCS3 (By similarity). Phosphorylation on Tyr-1141 is required for STAT3 binding/activation.
    • 細胞内局在
      Secreted and Cell membrane.
    • Information by UniProt
    • 参照データベース
    • 別名
      • CD 295 antibody
      • CD295 antibody
      • CD295 antigen antibody
      • Db antibody
      • Fa antibody
      • HuB219 antibody
      • LEP R antibody
      • LEP-R antibody
      • LEPR antibody
      • LEPR_HUMAN antibody
      • LEPRD antibody
      • Leptin receptor antibody
      • Leptin receptor fatty antibody
      • Leptin receptor gene related protein antibody
      • Leptin receptor precursor antibody
      • Leptin receptor precursor antibody
      • OB R gene related protein antibody
      • OB receptor antibody
      • OB-R antibody
      • OB-RGRP antibody
      • obl antibody
      • Obr antibody
      see all

    プロトコール

    参考文献

    ab7212 has not yet been referenced specifically in any publications.

    レビューと Q&A

    This antibody has not been tested for use in immunocytochemistry.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

    登録