製品の概要

  • 製品名Anti-Lefty antibody
    Lefty 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Lefty
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide corresponding to a region within the N terminal amino acids 1-50 (QPLWLCWALWVLPLASPGAALTGEQLLGSLLRQLQLKEVPTLDRADMEE L) of Human Lefty, NP_066277

  • ポジティブ・コントロール
    • Transfected 293T cell lysate

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab86326 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 41 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

ターゲット情報

  • 関連性During vertebrate embryogenesis, a left right axis is established. Secreted growth factors of the TGF beta family, including gene products derived from nodal, lefty 1 and lefty 2, play crucial roles in establishing left right asymmetries. TGF beta (Transforming growth factor beta) is a pleiotropic cytokine that regulates growth and differentiation of diverse types of cells. TGF beta actions are directed by ligand induced activation of TGF beta receptors. Complexes formed move into the nucleus, where they act as components of a transcriptional complex. Lefty, a novel member of the TGF beta superfamily, inhibits TGF beta signaling. Lefty acts to inhibit phosphorylation of Smad2 following activation of the TGF beta receptor. Lefty also inhibits events downstream from R Smad phosphorylation. Lefty provides a repressed state of TGF beta responsive genes. The Lefty family is comprised of Lefty 1 and Lefty 2 in mouse, and Lefty A and Lefty B in humans. Members of the TGF beta superfamily require processing for their activation. Cleavage is therefore an essential step for Lefty activation. Lefty is synthesized as a large inactive precursor (41 Kda) that must be endoproteolytically processed to release the bioactive polypeptide (28 kDa and 34 kDa forms). The 28kDa form induces MAPK activity.
  • 細胞内局在Secreted
  • 参照データベース
  • 別名
    • AI450052 antibody
    • Ebaf antibody
    • Left right determination factor 1 antibody
    • Left right determination factor antibody
    • Left right determination factor B antibody
    • left-right determination factor antibody
    • LEFT-RIGHT DETERMINATION FACTOR 1; LEFTY1 antibody
    • left-right determination, factor B antibody
    • LEFT-RIGHT DETERMINATION, FACTOR B; LEFTY B antibody
    • LEFTB antibody
    • LEFTY 1 antibody
    • Lefty antibody
    • lefty-1 antibody
    • LEFTY1 antibody
    • LEFTY1, MOUSE, HOMOLOG OF antibody
    • LEFTYB antibody
    • OTTHUMP00000035572 antibody
    • Protein lefty-1 antibody
    • Protein lefty-B antibody
    • RGD1561867 antibody
    • Stimulated by retinoic acid gene 3 protein antibody
    • STRA3 antibody
    • TGF beta 4 antibody
    • TGF-beta-4 antibody
    • Tgfb4 antibody
    • Transforming growth factor beta 4 antibody
    • Transforming growth factor beta-4 antibody
    see all

Anti-Lefty antibody 画像

  • Anti-Lefty antibody (ab86326) at 1 µg/ml + Transfected 293T cell lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 41 kDa

Anti-Lefty antibody (ab86326) 使用論文

ab86326 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"