製品の概要

  • 製品名
    Leelamine
  • 製品の詳細
    Pyruvate dehydrogenase kinase (PDK) inhibitor
  • 別名
    • Dehydroabietylamine
  • 生理活性の詳細
    Pyruvate dehydrogenase kinase (PDK) inhibitor (IC50 = 9.5 µM). It has weak affinity for human CB1 and CB2 receptors, exhibiting 20% displacement of [3H]-CP55940 at a concentration of 10 µM.
  • 精製度
    > 98%

製品の特性

  • 体系名
    (1R,4aS,10aR)-1,2,3,4,4a,9,10,10a-Octahydro-1,4a-dimethyl-7-(1-methylethyl)-1-phenanthrenemethanamine
  • 分子量
    285.47
  • 構造式
    Chemical Structure
  • 分子式
    C20H31N
  • CAS 番号
    1446-61-3
  • 保存方法
    Store at room temperature.
  • 溶解性
    Supplied in ethanol (50 mg/ml)
  • 使用に関する注意

    Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES 線形表記
    CC(C)C(C=C1)=CC2=C1[C@]3(C)[C@](CC2)([H])[C@@](CN)(C)CCC3
  • 由来

    Synthetic

  • 研究分野

参考文献

This product has been referenced in:
  • Cadoudal T  et al. Pyruvate dehydrogenase kinase 4: regulation by thiazolidinediones and implication in glyceroneogenesis in adipose tissue. Diabetes 57:2272-9 (2008). Read more (PubMed: 18519799) »
  • Aicher TD  et al. Triterpene and diterpene inhibitors of pyruvate dehydrogenase kinase (PDK). Bioorg Med Chem Lett 9:2223-8 (1999). Read more (PubMed: 10465550) »

See 0 Publications for this product

レビューと Q&A

The leelamine is probably coming out of solution at that temperature. We recommend storing it at room temperature. It will be stable for at least one year.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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