製品の概要

  • 製品名Leelamine
  • 製品の詳細
    Pyruvate dehydrogenase kinase (PDK) inhibitor
  • 別名
    • Dehydroabietylamine
  • 生理活性の詳細Pyruvate dehydrogenase kinase (PDK) inhibitor (IC50 = 9.5 µM). It has weak affinity for human CB1 and CB2 receptors, exhibiting 20% displacement of [3H]-CP55940 at a concentration of 10 µM.
  • 精製度> 98%

製品の特性

  • 体系名(1R,4aS,10aR)-1,2,3,4,4a,9,10,10a-Octahydro-1,4a-dimethyl-7-(1-methylethyl)-1-phenanthrenemethanamine
  • 分子量285.47
  • 構造式Chemical Structure
  • 分子式C20H31N
  • CAS 番号1446-61-3
  • 保存方法Store at room temperature.
  • 溶解性Supplied in ethanol (50 mg/ml)
  • 使用に関する注意

    Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES 線形表記CC(C)C(C=C1)=CC2=C1[C@]3(C)[C@](CC2)([H])[C@@](CN)(C)CCC3
  • 由来

    Synthetic

  • 研究分野

    Leelamine (ab120923) 使用論文

    This product has been referenced in:
    • Cadoudal T  et al. Pyruvate dehydrogenase kinase 4: regulation by thiazolidinediones and implication in glyceroneogenesis in adipose tissue. Diabetes 57:2272-9 (2008). Read more (PubMed: 18519799) »
    • Aicher TD  et al. Triterpene and diterpene inhibitors of pyruvate dehydrogenase kinase (PDK). Bioorg Med Chem Lett 9:2223-8 (1999). Read more (PubMed: 10465550) »

    See 0 Publications for this product

    Product Wall

    The leelamine is probably coming out of solution at that temperature. We recommend storing it at room temperature. It will be stable for at least one year.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"