製品の概要

  • 製品名Anti-LDL Receptor antibody
    LDL Receptor 一次抗体 製品一覧
  • 製品の詳細
    Chicken polyclonal to LDL Receptor
  • アプリケーション適用あり: ELISAmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Full length protein corresponding to Human LDL Receptor.
    Database link: P04114

アプリケーション

Our Abpromise guarantee covers the use of ab15870 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA Use a concentration of 0.5 - 1 µg/ml.

ターゲット情報

  • 機能Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. In case of HIV-1 infection, functions as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells.
  • 関連疾患Defects in LDLR are the cause of familial hypercholesterolemia (FH) [MIM:143890]; a common autosomal semi-dominant disease that affects about 1 in 500 individuals. The receptor defect impairs the catabolism of LDL, and the resultant elevation in plasma LDL-cholesterol promotes deposition of cholesterol in the skin (xanthelasma), tendons (xanthomas), and coronary arteries (atherosclerosis).
  • 配列類似性Belongs to the LDLR family.
    Contains 3 EGF-like domains.
    Contains 7 LDL-receptor class A domains.
    Contains 6 LDL-receptor class B repeats.
  • 翻訳後修飾N- and O-glycosylated.
    Ubiquitinated by MYLIP leading to degradation.
  • 細胞内局在Cell membrane. Endomembrane system. Membrane > clathrin-coated pit. Found distributed from the plasma membrane to intracellular compartments.
  • Information by UniProt
  • 参照データベース
  • 別名
    • FH antibody
    • FHC antibody
    • LDL R antibody
    • LDL receptor antibody
    • LDLCQ2 antibody
    • Ldlr antibody
    • LDLR_HUMAN antibody
    • Low Density Lipoprotein Receptor antibody
    • Low density lipoprotein receptor class A domain containing protein 3 antibody
    • Low density lipoprotein receptor familial hypercholesterolemia antibody
    • Low-density lipoprotein receptor antibody
    see all

Anti-LDL Receptor antibody (ab15870) 使用論文

This product has been referenced in:
  • Yuan Y  et al. Advanced glycation end products (AGEs) increase human mesangial foam cell formation by increasing Golgi SCAP glycosylation in vitro. Am J Physiol Renal Physiol 301:F236-43 (2011). Read more (PubMed: 21511699) »

See 1 Publication for this product

Product Wall

There are currently no Abreviews or Questions for ab15870.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"