製品の概要

製品の詳細

  • 由来Synthetic
  • アミノ酸配列
    • 生物種Human
    • 配列KSQNKPEDEADE
    • 領域251 to 262

関連製品

特性

Our Abpromise guarantee covers the use of ab45811 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking - Blocking peptide for Anti-LDB3 antibody (ab40840)

  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

関連情報

  • 別名
    • CMD1C
    • CYPHER
    • HGNC:15710
    • KIAA01613
    • KIAA0613
    • Ldb3
    • LDB3_HUMAN
    • LDB3Z1
    • LDB3Z4
    • LIM domain binding 3
    • LIM domain binding protein 3
    • LIM domain-binding protein 3
    • LVNC3
    • ORACLE
    • PDLIM6
    • PDZ and LIM domain 6
    • Protein cypher
    • Z band alternatively spliced PDZ motif
    • Z band alternatively spliced PDZ motif protein
    • Z-band alternatively spliced PDZ-motif protein
    • ZASP
    see all
  • 機能May function as an adapter in striated muscle to couple protein kinase C-mediated signaling via its LIM domains to the cytoskeleton.
  • 組織特異性Expressed primarily in skeletal muscle and to a lesser extent in heart. Also detected in brain and placenta.
  • 関連疾患Defects in LDB3 are the cause of cardiomyopathy dilated type 1C (CMD1C) [MIM:601493]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
    Defects in LDB3 are the cause of left ventricular non-compaction type 3 (LVNC3) [MIM:601493]. Left ventricular non-compaction is characterized by numerous prominent trabeculations and deep intertrabecular recesses in hypertrophied and hypokinetic segments of the left ventricle.
    Defects in LDB3 are the cause of myopathy myofibrillar ZASP-related (MFM-ZASP) [MIM:609452]. A neuromuscular disorder characterized by distal and proximal muscle weakness with signs of cardiomyopathy and neuropathy.
  • 配列類似性Contains 3 LIM zinc-binding domains.
    Contains 1 PDZ (DHR) domain.
  • 細胞内局在Cytoplasm > perinuclear region. Cell projection > pseudopodium. Cytoplasm > cytoskeleton. Cytoplasm > myofibril > sarcomere > Z line. Localized to the cytoplasm around nuclei and pseudopodia of undifferentiated cells and detected throughout the myotubes of differentiated cells. Colocalizes with ACTN2 at the Z-lines.
  • Information by UniProt

LDB3 peptide (251-262) (ab45811) 使用論文

ab45811 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab45811.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"