製品の概要

  • 製品名Anti-LDB3 antibody
    LDB3 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to LDB3
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Guinea pig, Cow, Cat
  • 免疫原

    A 14-22 amino acid region within synthetic peptide: SYNLSLTLQK SKRPIPISTT APPVQTPLPV IPHQKDPALD TNGSLVAPSP, corresponding to N terminal amino acids 73-122 of Human LDB3

  • ポジティブ・コントロール
    • Fetal heart cell lysate.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • バッファーPreservative: None
    Constituents: 2% Sucrose, PBS
  • Concentration information loading...
  • 精製度Protein A purified
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab62179 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 0.625 µg/ml. Detects a band of approximately 30 kDa (predicted molecular weight: 77 , 36 kDa). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

ターゲット情報

  • 機能May function as an adapter in striated muscle to couple protein kinase C-mediated signaling via its LIM domains to the cytoskeleton.
  • 組織特異性Expressed primarily in skeletal muscle and to a lesser extent in heart. Also detected in brain and placenta.
  • 関連疾患Defects in LDB3 are the cause of cardiomyopathy dilated type 1C (CMD1C) [MIM:601493]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
    Defects in LDB3 are the cause of left ventricular non-compaction type 3 (LVNC3) [MIM:601493]. Left ventricular non-compaction is characterized by numerous prominent trabeculations and deep intertrabecular recesses in hypertrophied and hypokinetic segments of the left ventricle.
    Defects in LDB3 are the cause of myopathy myofibrillar ZASP-related (MFM-ZASP) [MIM:609452]. A neuromuscular disorder characterized by distal and proximal muscle weakness with signs of cardiomyopathy and neuropathy.
  • 配列類似性Contains 3 LIM zinc-binding domains.
    Contains 1 PDZ (DHR) domain.
  • 細胞内局在Cytoplasm > perinuclear region. Cell projection > pseudopodium. Cytoplasm > cytoskeleton. Cytoplasm > myofibril > sarcomere > Z line. Localized to the cytoplasm around nuclei and pseudopodia of undifferentiated cells and detected throughout the myotubes of differentiated cells. Colocalizes with ACTN2 at the Z-lines.
  • Information by UniProt
  • 参照データベース
  • 別名
    • CMD1C antibody
    • CYPHER antibody
    • HGNC:15710 antibody
    • KIAA01613 antibody
    • KIAA0613 antibody
    • Ldb3 antibody
    • LDB3_HUMAN antibody
    • LDB3Z1 antibody
    • LDB3Z4 antibody
    • LIM domain binding 3 antibody
    • LIM domain binding protein 3 antibody
    • LIM domain-binding protein 3 antibody
    • LVNC3 antibody
    • ORACLE antibody
    • PDLIM6 antibody
    • PDZ and LIM domain 6 antibody
    • Protein cypher antibody
    • Z band alternatively spliced PDZ motif antibody
    • Z band alternatively spliced PDZ motif protein antibody
    • Z-band alternatively spliced PDZ-motif protein antibody
    • ZASP antibody
    see all

Anti-LDB3 antibody 画像

  • Anti-LDB3 antibody (ab62179) at 0.625 µg/ml + Fetal heart cell lysate at 10 µg/ml

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 77 , 36 kDa
    Observed band size : 30 kDa (why is the actual band size different from the predicted?)

Anti-LDB3 antibody (ab62179) 使用論文

ab62179 has not yet been referenced specifically in any publications.

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