Anti-LDB3 抗体 (ab110003)
Key features and details
- Goat polyclonal to LDB3
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-LDB3 antibody
LDB3 一次抗体 製品一覧 -
製品の詳細
Goat polyclonal to LDB3 -
由来種
Goat -
アプリケーション
適用あり: WB, IHC-Pmore details -
種交差性
交差種: Human
交差が予測される動物種: Dog, Pig -
免疫原
Synthetic peptide: C-
KSQNKPEDEADE
, corresponding to internal sequence amino acids 251-262 of Human LDB3 -
ポジティブ・コントロール
- Human skeletal muscle tissue, Human muscle lysate.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. -
バッファー
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: Tris buffered saline, 0.5% BSA -
Concentration information loading...
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精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab110003の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB |
Use a concentration of 0.01 - 0.03 µg/ml. Predicted molecular weight: 77 kDa.
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|
IHC-P |
Use a concentration of 3.75 µg/ml.
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特記事項 |
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WB
Use a concentration of 0.01 - 0.03 µg/ml. Predicted molecular weight: 77 kDa. |
IHC-P
Use a concentration of 3.75 µg/ml. |
ターゲット情報
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機能
May function as an adapter in striated muscle to couple protein kinase C-mediated signaling via its LIM domains to the cytoskeleton. -
組織特異性
Expressed primarily in skeletal muscle and to a lesser extent in heart. Also detected in brain and placenta. -
関連疾患
Defects in LDB3 are the cause of cardiomyopathy dilated type 1C (CMD1C) [MIM:601493]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
Defects in LDB3 are the cause of left ventricular non-compaction type 3 (LVNC3) [MIM:601493]. Left ventricular non-compaction is characterized by numerous prominent trabeculations and deep intertrabecular recesses in hypertrophied and hypokinetic segments of the left ventricle.
Defects in LDB3 are the cause of myopathy myofibrillar ZASP-related (MFM-ZASP) [MIM:609452]. A neuromuscular disorder characterized by distal and proximal muscle weakness with signs of cardiomyopathy and neuropathy. -
配列類似性
Contains 3 LIM zinc-binding domains.
Contains 1 PDZ (DHR) domain. -
細胞内局在
Cytoplasm > perinuclear region. Cell projection > pseudopodium. Cytoplasm > cytoskeleton. Cytoplasm > myofibril > sarcomere > Z line. Localized to the cytoplasm around nuclei and pseudopodia of undifferentiated cells and detected throughout the myotubes of differentiated cells. Colocalizes with ACTN2 at the Z-lines. - Information by UniProt
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参照データベース
- Entrez Gene: 11155 Human
- Omim: 605906 Human
- SwissProt: O75112 Human
- Unigene: 657271 Human
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別名
- CMD1C antibody
- CYPHER antibody
- HGNC:15710 antibody
see all
画像
プロトコール
データシートおよび資料
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Datasheet download
参考文献 (0)
ab110003 は論文での使用が確認できていません。