製品の概要

  • 製品名Anti-Lck (phospho Y505) antibody
    Lck 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Lck (phospho Y505)
  • 特異性Detects endogenous levels of Lck only when phosphorylated at tyrosine 505.
  • アプリケーション適用あり: IHC-P, ELISAmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse
  • 免疫原

    Synthetic phosphopeptide (Human) from around the phosphorylation site of tyrosine 505 (GQYPQP)

  • ポジティブ・コントロール
    • Human breast carcinoma tissue

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab59198 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P Use at an assay dependent concentration.
ELISA 1/60000.

ターゲット情報

  • 機能Tyrosine kinase that plays an essential role for the selection and maturation of developing T-cell in the thymus and in mature T-cell function. Is constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors and plays a key role in T-cell antigen receptor(TCR)-linked signal transduction pathways. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, and thereby recruits the associated LCK to the vicinity of the TCR/CD3 complex. LCK then phosphorylates tyrosines residues within the immunoreceptor tyrosines-based activation motifs (ITAMs) in the cytoplasmic tails of the TCRgamma chains and CD3 subunits, initiating the TCR/CD3 signaling pathway. In addition, contributes to signaling by other receptor molecules. Associates directly with the cytoplasmic tail of CD2, and upon engagement of the CD2 molecule, LCK undergoes hyperphosphorylation and activation. Also plays a role in the IL2 receptor-linked signaling pathway that controls T-cell proliferative response. Binding of IL2 to its receptor results in increased activity of LCK. Is expressed at all stages of thymocyte development and is required for the regulation of maturation events that are governed by both pre-TCR and mature alpha beta TCR. Phosphorylates RUNX3.
  • 組織特異性Expressed specifically in lymphoid cells.
  • 関連疾患Note=A chromosomal aberration involving LCK is found in leukemias. Translocation t(1;7)(p34;q34) with TCRB.
  • 配列類似性Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
    Contains 1 protein kinase domain.
    Contains 1 SH2 domain.
    Contains 1 SH3 domain.
  • ドメインThe SH2 domain mediates interaction with SQSTM1. Interaction is regulated by Ser-59 phosphorylation.
  • 翻訳後修飾Phosphorylated on Tyr-394, which increases enzymatic activity (By similarity). Phosphorylated on Tyr-505, which decreases activity.
  • 細胞内局在Cytoplasm. Cell membrane. Present in lipid rafts in an unactive form.
  • Information by UniProt
  • 参照データベース
  • 製品の状態This protein is known to be similar in amino acid sequence to HCK (P08631), FYN (P06241), YES1 (P07947), SRC (P12931), and LYN (P07948). Therefore, cross-reactivity with these homologous proteins may be observed. We would be happy to provide immunogen alignment information upon request.
  • 別名
    • IMD22 antibody
    • LCK antibody
    • Lck p56 antibody
    • LCK proto-oncogene, Src family tyrosine kinase antibody
    • LCK_HUMAN antibody
    • Leukocyte C-terminal Src kinase antibody
    • LSK antibody
    • Lymphocyte cell specific protein tyrosine kinase antibody
    • Lymphocyte cell-specific protein-tyrosine kinase antibody
    • Lymphocyte specific protein tyrosine kinase antibody
    • Membrane associated protein tyrosine kinase antibody
    • Oncogene lck antibody
    • P56 LCK antibody
    • p56(LSTRA) protein tyrosine kinase antibody
    • p56-LCK antibody
    • p56lck antibody
    • pp58 lck antibody
    • pp58lck antibody
    • Protein YT16 antibody
    • Proto oncogene tyrosine protein kinase LCK antibody
    • Proto-oncogene Lck antibody
    • Protooncogene tyrosine protein kinase LCK antibody
    • T cell specific protein tyrosine kinase antibody
    • T cell-specific protein-tyrosine kinase antibody
    • T lymphocyte specific protein tyrosine kinase p56lck antibody
    • Tyrosine-protein kinase Lck antibody
    • YT 16 antibody
    • YT16 antibody
    see all

Anti-Lck (phospho Y505) antibody 画像

  • Immunohistochemical analysis of paraffin embedded human breast carcinoma tissue using ab59198 at 1/50 dilution. Samples were untreated (left) or treated with immunizing peptide (right).

Anti-Lck (phospho Y505) antibody (ab59198) 使用論文

ab59198 has not yet been referenced specifically in any publications.

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