製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to LATS2
  • アプリケーション
    適用あり: IHC-P, ICC/IFmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse
  • 免疫原

    Synthetic peptide derived from an internal sequence of Human LATS2.

  • ポジティブ・コントロール
    • HepG2 cells; Human skeletal muscle tissue.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab111054 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
ICC/IF 1/100 - 1/500.

ターゲット情報

  • 機能
    Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor.
  • 組織特異性
    Expressed at high levels in heart and skeletal muscle and at lower levels in all other tissues examined.
  • 配列類似性
    Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
    Contains 1 AGC-kinase C-terminal domain.
    Contains 1 protein kinase domain.
    Contains 1 UBA domain.
  • 翻訳後修飾
    Autophosphorylated and phosphorylated during M-phase and the G1/S-phase of the cell cycle. Phosphorylated and activated by STK3.
  • 細胞内局在
    Cytoplasm > cytoskeleton > centrosome. Cytoplasm. Cytoplasm > cytoskeleton > spindle pole. Co-localizes with STK6 at the centrosomes during interphase, early prophase and cytokinesis. Migrates to the spindle poles during mitosis, and to the midbody during cytokinesis.
  • Information by UniProt
  • 参照データベース
  • 別名
    • FLJ13161 antibody
    • Kinase phosphorylated during mitosis protein antibody
    • KPM antibody
    • Large tumor suppressor homolog 2 antibody
    • Large tumor suppressor homolog 2 Drosophila antibody
    • Large tumor suppressor kinase 2 antibody
    • LATS large tumor suppressor Drosophila homolog 2 antibody
    • LATS large tumor suppressor homolog 2 antibody
    • Lats2 antibody
    • LATS2_HUMAN antibody
    • Serine/threonine kinase kpm antibody
    • Serine/threonine protein kinase kpm antibody
    • Serine/threonine-protein kinase kpm antibody
    • Serine/threonine-protein kinase LATS2 antibody
    • Warts like kinase antibody
    • Warts-like kinase antibody
    see all

画像

  • ab111054 at 1/100 dilution staining LATS2 in HepG2 cells by Immunofluorescence. The image on the right is treated with the synthesized peptide.
  • ab110541 at 1/50 dilution staining LATS2 in paraffin-embedded Human Skeletal muscle tissue by Immunohistochemistry. The image on the right is treated with the synthesized peptide.

参考文献

ab111054 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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