Latrunculin A (LAT-A), Actin polymerization inhibitor (ab144290)
Key features and details
- Actin polymerization inhibitor. Potent antiproliferative agent.
- CAS Number: 76343-93-6
- Purity: > 95%
- Soluble in ethanol to 10 mM and in DMSO to 10 mM
- Form / State: Solid
- Source: Cacospongia mycofijiensis
製品の概要
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製品名
Latrunculin A (LAT-A), Actin polymerization inhibitor -
製品の詳細
Actin polymerization inhibitor. Potent antiproliferative agent. -
生理活性の詳細
Actin polymerization inhibitor. Potent antiproliferative agent. Stabilizes monomeric G-actin. Shows greater potency than Latrunculin B (ab144291). Binds actin monomers near the nucleotide binding cleft with 1:1 stoichiometry. Inhibits growth of cancer cell lines (IC50 values are 142, 142, 142, 166 and 95 nM for A549, H522-T1, HT-29, U-937 and MDA-MB-43 cells respectively). Shows convulsant effects in vivo.
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精製度
> 95% -
CAS 番号
76343-93-6 -
構造式
製品の特性
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体系名
(4R)-4-[(1R,4Z,8E,10Z,12S,15R,17R)-17-Hydroxy-5,12-dimethyl-3-oxo-2,16-dioxabicyclo[13.3.1]nonadeca-4,8,10-trien-17-yl]-2-thiazolidinone -
分子量
421.55 -
分子式
C22H31NO5S -
PubChem 登録番号
445420 -
保存方法
Store at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions. -
溶解性
Soluble in ethanol to 10 mM and in DMSO to 10 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
C[C@H]/1CC[C@@H]2C[C@H](C[C@@](O2)([C@@H]3CSC(=O)N3)O)OC(=O)/C=C(\CC/C=C/C=C1)/C -
由来
Cacospongia mycofijiensis
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研究分野
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (22)
ab144290 は 22 報の論文で使用されています。
- Davaa G et al. Delivery of Induced Neural Stem Cells Through Mechano-Tuned Silk-Collagen Hydrogels for the Recovery of Contused Spinal Cord in Rats. Adv Healthc Mater 12:e2201720 (2023). PubMed: 36447307
- Phillips C et al. The Wnt Pathway Inhibitor RXC004 Blocks Tumor Growth and Reverses Immune Evasion in Wnt Ligand-dependent Cancer Models. Cancer Res Commun 2:914-928 (2022). PubMed: 36922934
- de Los Ángeles Juricic Urzúa M et al. The dendritic ERGIC: Microtubule and actin cytoskeletons participate in stop-and-go movement of mobile carriers between stable structures. Traffic 23:174-187 (2022). PubMed: 35075729
- Shi L et al. Filamin FLN-2 promotes MVB biogenesis by mediating vesicle docking on the actin cytoskeleton. J Cell Biol 221:N/A (2022). PubMed: 35575797
- Pineau J et al. Microtubules restrict F-actin polymerization to the immune synapse via GEF-H1 to maintain polarity in lymphocytes. Elife 11:N/A (2022). PubMed: 36111670