Anti-LAT 抗体 (ab17032)

製品の概要

• 製品名
  Anti-LAT antibody
  LAT 一次抗体 製品一覧
• 製品の詳細
  Goat polyclonal to LAT
• 特異性
  This antibody is expected to recognize isoform a (NP_055202.1), isoform b (NP_001014987.1 and NP_001014989.1) and isoform c (NP_001014988.1).
• アプリケーション
  適用あり: WBmore details
• 種交差性
  交差種: Human
  交差が予測される動物種: Mouse, Rat
• 免疫原

  Synthetic peptide:

  GAPDYENLQELN

  , corresponding to amino acids 251-262 of Human LAT.

  Run BLAST with Run BLAST with

製品の特性

• 製品の状態
  Liquid
• 保存方法
  Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• バッファー
  Preservative: 0.02% Sodium Azide
  Constituents: 0.5% BSA, Tris buffered saline. pH 7.3
• Concentration information loading...
• 精製度
  Immunogen affinity purified
• ポリ/モノ
  ポリクローナル
• アイソタイプ
  IgG
• 研究分野
  • Immunology
  • Adaptive Immunity
  • T Cells
  • Non-CD

  • Signal Transduction
  • Adapters
  • Transmembrane

  • Signal Transduction
  • Signaling Pathway
  • G Protein Signaling
  • Small G Proteins
  • Ras Family

関連製品

• Compatible Secondaries
  • Donkey Anti-Goat IgG H&L (Alexa Fluor® 488) (ab150129)
  • Donkey Anti-Goat IgG H&L (HRP) (ab205723)

アプリケーション

ターゲット情報

• 機能
  Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules.
• 組織特異性
  Expressed in thymus, T-cells, NK cells, mast cells and, at lower levels, in spleen. Present in T-cells but not B-cells (at protein level).
• 翻訳後修飾
  Phosphorylated on tyrosines by ZAP-70 upon TCR activation, or by SYK upon other immunoreceptor activation; which leads to the recruitment of multiple signaling molecules. Is one of the most prominently tyrosine-phosphorylated proteins detected following TCR engagement. May be dephosphorylated by PTPRJ.
  Palmitoylation of Cys-26 and Cys-29 is required for raft targeting and efficient phosphorylation.
• 細胞内局在
  Cell membrane. Present in lipid rafts.

• Target information above from: UniProt accession O43561 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 参照データベース
  • Entrez Gene: 27040 Human
  • Entrez Gene: 16797 Mouse
  • Entrez Gene: 81511 Rat
  • Omim: 602354 Human
  • SwissProt: O43561 Human
  • SwissProt: O54957 Mouse
  • SwissProt: O70601 Rat
  • Unigene: 632179 Human

  • Unigene: 10280 Mouse
  • Unigene: 9773 Rat

  see all
• 別名
  • 36 kDa phospho tyrosine adapter protein antibody
  • 36 kDa phospho-tyrosine adapter protein antibody
  • 36 kDa phospho-tyrosine adaptor protein antibody

  • LAT 1 antibody
  • lat antibody
  • LAT_HUMAN antibody
  • LAT1 antibody
  • Linker for activation of T cells antibody
  • Linker for activation of T cells family member 1 antibody
  • linker for activation of T cells, transmembrane adaptor antibody
  • Linker for activation of T-cells family member 1 antibody
  • p36 38 antibody
  • p36-38 antibody
  • pp36 antibody

  see all

プロトコール

• Western blot protocols