製品の概要

  • 製品名Anti-Langerin antibody
    Langerin 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Langerin
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Pig, Chimpanzee, Rhesus monkey
  • 免疫原

    Synthetic peptide conjugated to KLH derived from within residues 1 - 100 of Human Langerin.

    (Peptide available as ab73966.)

  • ポジティブ・コントロール
    • This antibody gave a positive signal in the following Lysates: Human Lung Tissue, DU 145 Whole Cell

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab68434 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Detects a band of approximately 36 kDa (predicted molecular weight: 36 kDa).

ターゲット情報

  • 機能Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation.
  • 組織特異性Exclusively expressed by Langerhans cells. Expressed in astrocytoma and malignant ependymoma, but not in normal brain tissues.
  • 関連疾患Defects in CD207 are the cause of Birbeck granule deficiency (BIRGD) [MIM:613393]. It is a condition characterized by the absence of Birbeck granules in epidermal Langerhans cells. Despite the lack of Birbeck granules Langerhans cells are present in normal numbers and have normal morphologic characteristics and antigen-presenting capacity.
  • 配列類似性Contains 1 C-type lectin domain.
  • ドメインThe C-type lectin domain mediates dual recognition of both sulfated and mannosylated glycans.
  • 細胞内局在Membrane. Found in Birbeck granules (BGs), which are organelles consisting of superimposed and zippered membranes.
  • Information by UniProt
  • 参照データベース
  • 別名
    • C type lectin domain family 4 member K antibody
    • C-type lectin domain family 4 member K antibody
    • CD 207 antibody
    • CD207 antibody
    • CD207 antigen antibody
    • CD207 antigen, langerin antibody
    • CD207 molecule antibody
    • CLC4K_HUMAN antibody
    • CLEC 4K antibody
    • CLEC4K antibody
    • Langerhans cell specific c type lectin antibody
    • Langerin antibody
    • RGD1565913 antibody
    see all

Anti-Langerin antibody 画像

  • All lanes : Anti-Langerin antibody (ab68434) at 1 µg/ml

    Lane 1 : Lung (Human) Tissue Lysate
    Lane 2 : DU 145 (Human prostate carcinoma cell line) Whole Cell Lysate

    Lysates/proteins at 10 µg per lane.

    Secondary
    Goat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution
    Developed using the ECL technique

    Performed under reducing conditions.

    Predicted band size : 36 kDa
    Observed band size : 36 kDa
    Additional bands at : 50 kDa,60 kDa. We are unsure as to the identity of these extra bands.

    Exposure time : 20 minutes

Anti-Langerin antibody (ab68434) 使用論文

ab68434 has not yet been referenced specifically in any publications.

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Vielen Dank für Ihre Anrufe.

Wie versprochen habe ich alle unsere Langerin- bzw. TACD2-Antikörper danach geprüft, ob sie schon einmal mit Schwein getestet wurden - was leider bei keinem der Fall ist.

Daher habe ich di...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"