製品の概要

  • 製品名Anti-LAMP2 antibody [ABL-93] (FITC)
    LAMP2 一次抗体 製品一覧
  • 製品の詳細
    Rat monoclonal [ABL-93] to LAMP2 (FITC)
  • 標識FITC. Ex: 493nm, Em: 528nm
  • 特異性ab24945 recognises LAMP2 protein.
  • アプリケーション適用あり: Flow Cyt, IHC-Fr, IPmore details
  • 種交差性
    交差種: Mouse
  • 免疫原

    Full length native protein: Glycoproteins purified from BALB/c mouse embryo 3T3 cell line

アプリケーション

Our Abpromise guarantee covers the use of ab24945 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
Flow Cyt
IHC-Fr
IP
  • 追加情報Flow Cyt: Use 1µg for 106 cells.
    IHC-Fr: Use at an assay dependent dilution.
    Note: Acetone is recommended for fixation of tissues.
    IP: Use at an assay dependent dilution.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter-and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens.
    • 組織特異性Isoform LAMP-2A is highly expressed in placenta, lung and liver, less in kidney and pancreas, low in brain and skeletal muscle. Isoform LAMP-2B is highly expressed in skeletal muscle, less in brain, placenta, lung, kidney and pancreas, very low in liver.
    • 関連疾患Defects in LAMP2 are the cause of Danon disease (DAND) [MIM:300257]; also known as glycogen storage disease type 2B (GSD2B). DAND is a lysosomal glycogen storage disease characterized by the clinical triad of cardiomyopathy, vacuolar myopathy and mental retardation. It is often associated with an accumulation of glycogen in muscle and lysosomes.
    • 配列類似性Belongs to the LAMP family.
    • 翻訳後修飾O- and N-glycosylated; some of the 16 N-linked glycans are polylactosaminoglycans.
    • 細胞内局在Cell membrane. Endosome membrane. Lysosome membrane. This protein shuttles between lysosomes, endosomes, and the plasma membrane.
    • Information by UniProt
    • 参照データベース
    • 製品の状態Alternative splicing produces 3 isoforms.
    • 別名
      • CD107 antigen-like family member B antibody
      • CD107b antibody
      • LAMP 2 antibody
      • LAMP 2C antibody
      • LAMP-2 antibody
      • LAMP2 antibody
      • LAMP2_HUMAN antibody
      • LAMPB antibody
      • LGP110 antibody
      • Lysosomal associated membrane protein 2 antibody
      • Lysosome associated membrane protein 2 antibody
      • Lysosome-associated membrane glycoprotein 2 antibody
      • Lysosome-associated membrane protein 2 antibody
      • MAC3 antibody
      see all

    Anti-LAMP2 antibody [ABL-93] (FITC) (ab24945) 使用論文

    ab24945 has not yet been referenced specifically in any publications.

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    There are currently no Abreviews or Questions for ab24945.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"