Anti-Lamin B1 (phospho T575) 抗体 (ab111278)

製品の概要

  • 製品名Anti-Lamin B1 (phospho T575) antibody
    Lamin B1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Lamin B1 (phospho T575)
  • アプリケーション適用あり: WB, ELISA, ICCmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Rat
  • 免疫原

    Synthetic peptide corresponding to Human Lamin B1 (C terminal) (phospho T575).
    Database link: P20700

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab111278 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use at an assay dependent dilution. Predicted molecular weight: 66 kDa.
ELISA Use at an assay dependent dilution.
ICC Use at an assay dependent dilution.

ターゲット情報

  • 機能Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.
  • 関連疾患Defects in LMNB1 are the cause of leukodystrophy demyelinating autosomal dominant adult-onset (ADLD) [MIM:169500]. ADLD is a slowly progressive and fatal demyelinating leukodystrophy, presenting in the fourth or fifth decade of life. Clinically characterized by early autonomic abnormalities, pyramidal and cerebellar dysfunction, and symmetric demyelination of the CNS. It differs from multiple sclerosis and other demyelinating disorders in that neuropathology shows preservation of oligodendroglia in the presence of subtotal demyelination and lack of astrogliosis.
  • 配列類似性Belongs to the intermediate filament family.
  • 翻訳後修飾B-type lamins undergo a series of modifications, such as farnesylation and phosphorylation. Increased phosphorylation of the lamins occurs before envelope disintegration and probably plays a role in regulating lamin associations.
  • 細胞内局在Nucleus inner membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • ADLD antibody
    • lamin B1 antibody
    • Lamin-B1 antibody
    • LMN antibody
    • LMN2 antibody
    • LMNB antibody
    • Lmnb1 antibody
    • LMNB1_HUMAN antibody
    • MGC111419 antibody
    • OTTHUMP00000159218 antibody
    see all

Anti-Lamin B1 (phospho T575) antibody (ab111278) 使用論文

ab111278 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"