製品の概要

  • 製品名L779450
  • 製品の詳細
    Potent Raf kinase inhibitor
  • 生理活性の詳細Potent Raf kinase inhibitor (IC50 = 10 nM). Inhibits Raf-1 activation. Competes for ATP at the protein kinase catalytic site. Supresses DNA synthesis and induces apoptosis. Additionally inhibits p38.
  • 精製度> 98%

製品の特性

    L779450 (ab120837) 使用論文

    This product has been referenced in:
    • Sathishkumar K  et al. Raf-1 kinase regulates smooth muscle contraction in the rat mesenteric arteries. J Vasc Res 47:384-98 (2010). Read more (PubMed: 20110729) »
    • White MK Small-molecule inhibitors of signal transduction pathways in leukemia therapeutics: how to assess selectivity for malignant signals. Leukemia 17:1759-61 (2003). Read more (PubMed: 12970775) »
    • Shelton JG  et al. Differential effects of kinase cascade inhibitors on neoplastic and cytokine-mediated cell proliferation. Leukemia 17:1765-82 (2003). Read more (PubMed: 12970777) »

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