製品の概要

  • 製品名Anti-l + S Afadin antibody
    l + S Afadin 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to l + S Afadin
  • 特異性Anti l/s Afadin specifically recognizes l afadin and s afadin by immunoblotting (approximately 200 and 190 kDa respectively). Staining of the l/s afadin bands is specifically inhibited by the immunizing peptide.
  • アプリケーション適用あり: WB, ICC/IFmore details
  • 種交差性
    交差種: Mouse, Rat, Dog, Human
  • 免疫原

    Synthetic peptide:

    CKLPGDDRLMKNRADHRS

    conjugated to maleimide-activated BSA, corresponding to amino acids 1163-1179 of Rat l + S Afadin (with N-terminal added cysteine).

  • 特記事項Storage in frost-free freezers is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab11338 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/1000. Detects a band of approximately 200 (l), 190 (s) kDa.
ICC/IF Use at an assay dependent dilution.

ターゲット情報

  • 機能Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton.
  • 関連疾患Note=A chromosomal aberration involving MLLT4 is associated with acute leukemias. Translocation t(6;11)(q27;q23) with MLL/HRX. The result is a rogue activator protein.
  • 配列類似性Contains 1 dilute domain.
    Contains 1 FHA domain.
    Contains 1 PDZ (DHR) domain.
    Contains 2 Ras-associating domains.
  • ドメインThe PDZ/DHR domain interacts with the C-terminus of nectin and the Pro-rich C-terminus domain interacts with F-actin.
  • 細胞内局在Cell junction > adherens junction. Not found at cell-matrix AJs.
  • Information by UniProt
  • 参照データベース
  • 別名
    • AF6 antibody
    • AFAD_HUMAN antibody
    • Afadin antibody
    • ALL1-fused gene from chromosome 6 protein antibody
    • Mllt4 antibody
    • Protein Af-6 antibody
    • Protein AF6 antibody
    see all

Anti-l + S Afadin antibody (ab11338) 使用論文

This product has been referenced in:
  • Lachke SA  et al. The cell adhesion gene PVRL3 is associated with congenital ocular defects. Hum Genet : (2011). IHC-Fr ; Mouse . Read more (PubMed: 21769484) »
  • Sasaki AT  et al. Ubiquitination of K-Ras enhances activation and facilitates binding to select downstream effectors. Sci Signal 4:ra13 (2011). Read more (PubMed: 21386094) »

See all 2 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"