製品の概要

  • 製品名
    Anti-L-Kynurenine Hydrolase antibody
    L-Kynurenine Hydrolase 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to L-Kynurenine Hydrolase
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat
  • 免疫原

    Recombinant fragment, corresponding to a region within amino acids 114 and 299 of Human L-Kynurenine Hydrolase (AAH00879).

  • ポジティブ・コントロール
    • A549 cell lysate

法規制情報

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab96365 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/3000. Predicted molecular weight: 35 kDa.

ターゲット情報

  • 機能
    Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity.
  • 組織特異性
    Expressed in all tissues tested (heart, brain placenta, lung, liver, skeletal muscle, kidney and pancreas). Highest levels found in placenta, liver and lung. Expressed in all brain regions.
  • パスウェイ
    Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1.
    Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3.
  • 関連疾患
    Note=Xanthurenic aciduria manifesting as massive urinary excretion of large amounts of kynurenine, 3-hydroxykynurenine and xanthurenic acid has been observed in an individual carrying a homozygous missense change in KYNU (PubMed:17334708). The urinary pattern in the patient suggests kynureninase deficiency and a block in the conversion of kynurenine and 3-hydroxykynurenine to anthranilate and 3-hydroxyanthranilate, respectively.
  • 配列類似性
    Belongs to the kynureninase family.
  • 細胞内局在
    Cytoplasm.
  • Information by UniProt
  • 参照データベース
  • 別名
    • kynU antibody
    • KYNU_HUMAN antibody
    • kynureninase (L-kynurenine hydrolase) antibody
    • Kynureninase antibody
    • L-kynurenine hydrolase antibody
    see all

画像

  • Anti-L-Kynurenine Hydrolase antibody (ab96365) at 1/1000 dilution + A549 whole cell lysate at 30 µg

    Predicted band size : 35 kDa

プロトコール

参考文献

This product has been referenced in:
  • Nagy-Grócz G  et al. The Effect of Systemic Nitroglycerin Administration on the Kynurenine Pathway in the Rat. Front Neurol 8:278 (2017). WB ; Rat . Read more (PubMed: 28659861) »

See 1 Publication for this product

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