製品の概要

  • 製品名Anti-L-Kynurenine Hydrolase antibody
    L-Kynurenine Hydrolase 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal to L-Kynurenine Hydrolase
  • アプリケーション適用あり: WB, ICC/IFmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant fragment, corresponding to amino acids 2-109 of Human L-Kynurenine Hydrolase

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab56450 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
ICC/IF
  • 追加情報WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity.
    • 組織特異性Expressed in all tissues tested (heart, brain placenta, lung, liver, skeletal muscle, kidney and pancreas). Highest levels found in placenta, liver and lung. Expressed in all brain regions.
    • パスウェイAmino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1.
      Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3.
    • 関連疾患Note=Xanthurenic aciduria manifesting as massive urinary excretion of large amounts of kynurenine, 3-hydroxykynurenine and xanthurenic acid has been observed in an individual carrying a homozygous missense change in KYNU (PubMed:17334708). The urinary pattern in the patient suggests kynureninase deficiency and a block in the conversion of kynurenine and 3-hydroxykynurenine to anthranilate and 3-hydroxyanthranilate, respectively.
    • 配列類似性Belongs to the kynureninase family.
    • 細胞内局在Cytoplasm.
    • Information by UniProt
    • 参照データベース
    • 別名
      • kynU antibody
      • KYNU_HUMAN antibody
      • kynureninase (L-kynurenine hydrolase) antibody
      • Kynureninase antibody
      • L-kynurenine hydrolase antibody
      see all

    Anti-L-Kynurenine Hydrolase antibody 画像

    • Western blot against tagged recombinant protein immunogen using ab56450 L-Kynurenine Hydrolase antibody at 1ug/ml. Predicted band size of immunogen is 38 kDa

    Anti-L-Kynurenine Hydrolase antibody (ab56450) 使用論文

    This product has been referenced in:
    • Yang G  et al. Identification of autoantigens recognized by the 2F5 and 4E10 broadly neutralizing HIV-1 antibodies. J Exp Med 210:241-56 (2013). ICC/IF . Read more (PubMed: 23359068) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"