製品の概要

  • 製品名L-cis-Diltiazem
  • 製品の詳細
    Selective cyclic nucleotide-gated channel blocker
  • 生理活性の詳細Selective inhibitor of cyclic nucleotide-gated (CNG) channels. Blocks rod-type CNGA1, olfactory-type CNGA2 and cone-type CNGA3, at micromolar concentrations. Optical isomer of diltiazem (ab120260). Protects against myocardial dysfunction in vitro.
  • 精製度> 98%

製品の特性

  • 体系名(2R,3R)-(-)-cis-3-Acetoxy-5-(2-dimethylaminoethyl)-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one hydrochloride
  • 分子量450.98
  • 構造式Chemical Structure
  • 分子式C22H26N2O4S.HCl
  • CAS 番号42399-54-2
  • 保存方法Store at Room Temperature. The product can be stored for up to 12 months.
  • 溶解性Soluble in water to 100 mM
  • 使用に関する注意

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • 由来

    Synthetic

  • 研究分野

    関連製品

    L-cis-Diltiazem (ab120532) 使用論文

    This product has been referenced in:
    • Shalom R  et al. Interaction between prostaglandin E2 and l-cis-diltiazem, a specific blocker of cyclic nucleotide gated channels in bovine aortic endothelial cells. Eur J Pharmacol 543:8-13 (2006). Read more (PubMed: 16842773) »
    • Gomora JC & Enyeart JJ Dual pharmacological properties of a cyclic AMP-sensitive potassium channel. J Pharmacol Exp Ther 290:266-75 (1999). Read more (PubMed: 10381786) »
    • Haynes LW Block of the cyclic GMP-gated channel of vertebrate rod and cone photoreceptors by l-cis-diltiazem. J Gen Physiol 100:783-801 (1992). Read more (PubMed: 1282145) »
    • Frings S  et al. Properties of cyclic nucleotide-gated channels mediating olfactory transduction. Activation, selectivity, and blockage. J Gen Physiol 100:45-67 (1992). Read more (PubMed: 1324972) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"