製品の概要

  • 製品名
    L-741,626
  • 製品の詳細
    Potent and selective D2 antagonist
  • 生理活性の詳細
    Potent and selective D2 antagonist (Ki values are 2.4, 100 and 220 nM at D2, D3 and D4 receptors, respectively). Centrally active following in vivo systemic administration.
  • 精製度
    > 99%

製品の特性

参考文献

This product has been referenced in:
  • Collins GT  et al. Yawning and hypothermia in rats: effects of dopamine D3 and D2 agonists and antagonists. Psychopharmacology (Berl) 193:159-70 (2007). Read more (PubMed: 17393143) »
  • Caine SB  et al. Role of dopamine D2-like receptors in cocaine self-administration: studies with D2 receptor mutant mice and novel D2 receptor antagonists. J Neurosci 22:2977-88 (2002). Read more (PubMed: 11923462) »
  • LaHoste GJ  et al. Dopamine D1 receptors synergize with D2, but not D3 or D4, receptors in the striatum without the involvement of action potentials. J Neurosci 20:6666-71 (2000). Read more (PubMed: 10964971) »

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